| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FBL | NHP2L1 | ENSP00000221801 | ENSP00000215956 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | 0.998 |
| FBL | PRPF31 | ENSP00000221801 | ENSP00000324122 | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.893 |
| FSCN2 | IMPDH1 | ENSP00000334665 | ENSP00000345096 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | 0.608 |
| FSCN2 | PRPF3 | ENSP00000334665 | ENSP00000315379 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.715 |
| FSCN2 | PRPF31 | ENSP00000334665 | ENSP00000324122 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.780 |
| FSCN2 | PRPF8 | ENSP00000334665 | ENSP00000304350 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.657 |
| FSCN2 | RP9 | ENSP00000334665 | ENSP00000297157 | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | retinitis pigmentosa 9 (autosomal dominant); Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) | 0.569 |
| IMPDH1 | FSCN2 | ENSP00000345096 | ENSP00000334665 | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | 0.608 |
| IMPDH1 | PRPF3 | ENSP00000345096 | ENSP00000315379 | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.613 |
| IMPDH1 | PRPF31 | ENSP00000345096 | ENSP00000324122 | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.829 |
| IMPDH1 | PRPF8 | ENSP00000345096 | ENSP00000304350 | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.739 |
| IMPDH1 | RP9 | ENSP00000345096 | ENSP00000297157 | IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) | retinitis pigmentosa 9 (autosomal dominant); Is thought to be a target protein for the PIM1 kinase. May play some roles in B-cell proliferation in association with PIM1 (By similarity) | 0.658 |
| NHP2L1 | FBL | ENSP00000215956 | ENSP00000221801 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | fibrillarin; Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2’- hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA | 0.998 |
| NHP2L1 | PRPF3 | ENSP00000215956 | ENSP00000315379 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | 0.494 |
| NHP2L1 | PRPF31 | ENSP00000215956 | ENSP00000324122 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | PRP31 pre-mRNA processing factor 31 homolog (S. cerevisiae) | 0.986 |
| NHP2L1 | PRPF4 | ENSP00000215956 | ENSP00000363313 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | PRP4 pre-mRNA processing factor 4 homolog (yeast); Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome | 0.999 |
| NHP2L1 | PRPF6 | ENSP00000215956 | ENSP00000266079 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) | 0.967 |
| NHP2L1 | PRPF8 | ENSP00000215956 | ENSP00000304350 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | PRP8 pre-mRNA processing factor 8 homolog (S. cerevisiae); Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex. Functions as scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5’ and the 3’ splice site | 0.938 |
| NHP2L1 | SART1 | ENSP00000215956 | ENSP00000310448 | NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); Binds to the 5’-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding | squamous cell carcinoma antigen recognized by T cells; Plays a role in mRNA splicing as a component of the U4/U6-U5 tri-snRNP, one of the building blocks of the spliceosome. May also bind to DNA | 0.945 |
| PRPF3 | FSCN2 | ENSP00000315379 | ENSP00000334665 | PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae) | fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus) | 0.715 |
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