PSD3 protein (Homo sapiens) - STRING network view

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PSD3

pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity) (1047 aa)

Predicted Functional Partners:

ARAP1

0.632

UBC

0.549

PCSK5

0.457

PCSK7

0.457

PCSK1

0.457

PCSK6

0.457

PCSK4

0.457

FURIN

0.457

PCSK2

0.457

RANBP2

0.404

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARAP1	PSD3	ENSP00000377233	ENSP00000324127	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.632
ARAP1	UBC	ENSP00000377233	ENSP00000344818	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	ubiquitin C	0.513
FURIN	PCSK5	ENSP00000268171	ENSP00000446280	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	0.931
FURIN	PCSK6	ENSP00000268171	ENSP00000305056	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 6	0.932
FURIN	PCSK7	ENSP00000268171	ENSP00000325917	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.459
FURIN	PSD3	ENSP00000268171	ENSP00000324127	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.457
FURIN	UBC	ENSP00000268171	ENSP00000344818	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	ubiquitin C	0.666
PCSK1	PCSK7	ENSP00000308024	ENSP00000325917	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.429
PCSK1	PSD3	ENSP00000308024	ENSP00000324127	proprotein convertase subtilisin/kexin type 1; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.457
PCSK2	PCSK7	ENSP00000262545	ENSP00000325917	proprotein convertase subtilisin/kexin type 2	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.430
PCSK2	PSD3	ENSP00000262545	ENSP00000324127	proprotein convertase subtilisin/kexin type 2	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.457
PCSK4	PCSK7	ENSP00000300954	ENSP00000325917	proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.433
PCSK4	PSD3	ENSP00000300954	ENSP00000324127	proprotein convertase subtilisin/kexin type 4; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Plays a role in transcriptional coactivation. May be involved in stabilizing the multiprotein transcription complex	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.457
PCSK5	FURIN	ENSP00000446280	ENSP00000268171	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.931
PCSK5	PCSK6	ENSP00000446280	ENSP00000305056	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	proprotein convertase subtilisin/kexin type 6	0.930
PCSK5	PCSK7	ENSP00000446280	ENSP00000325917	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.402
PCSK5	PSD3	ENSP00000446280	ENSP00000324127	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	pleckstrin and Sec7 domain containing 3; Guanine nucleotide exchange factor for ARF6 (By similarity)	0.457
PCSK6	FURIN	ENSP00000305056	ENSP00000268171	proprotein convertase subtilisin/kexin type 6	furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif	0.932
PCSK6	PCSK5	ENSP00000305056	ENSP00000446280	proprotein convertase subtilisin/kexin type 6	proprotein convertase subtilisin/kexin type 5; Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins	0.930
PCSK6	PCSK7	ENSP00000305056	ENSP00000325917	proprotein convertase subtilisin/kexin type 6	proprotein convertase subtilisin/kexin type 7; Likely to represent a ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RXXX[KR]R consensus motif	0.400

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