| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COCH | ESRRB | ENSP00000216361 | ENSP00000370270 | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.680 |
| COCH | SIX1 | ENSP00000216361 | ENSP00000247182 | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | 0.457 |
| COCH | SLC22A17 | ENSP00000216361 | ENSP00000206544 | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.754 |
| COCH | STXBP6 | ENSP00000216361 | ENSP00000324302 | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | syntaxin binding protein 6 (amisyn); Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.752 |
| ESRRB | COCH | ENSP00000370270 | ENSP00000216361 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | 0.680 |
| ESRRB | SIX1 | ENSP00000370270 | ENSP00000247182 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | 0.439 |
| ESRRB | SLC22A17 | ENSP00000370270 | ENSP00000206544 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.748 |
| ESRRB | STXBP6 | ENSP00000370270 | ENSP00000324302 | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | syntaxin binding protein 6 (amisyn); Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.747 |
| SIX1 | COCH | ENSP00000247182 | ENSP00000216361 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | 0.457 |
| SIX1 | ESRRB | ENSP00000247182 | ENSP00000370270 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.439 |
| SIX1 | SLC22A17 | ENSP00000247182 | ENSP00000206544 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | 0.561 |
| SIX1 | STXBP6 | ENSP00000247182 | ENSP00000324302 | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | syntaxin binding protein 6 (amisyn); Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.519 |
| SLC22A17 | COCH | ENSP00000206544 | ENSP00000216361 | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | coagulation factor C homolog, cochlin (Limulus polyphemus); Plays a role in the control of cell shape and motility in the trabecular meshwork | 0.754 |
| SLC22A17 | ESRRB | ENSP00000206544 | ENSP00000370270 | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | estrogen-related receptor beta; Nuclear receptor, may regulate ESR1 transcriptional activity | 0.748 |
| SLC22A17 | SIX1 | ENSP00000206544 | ENSP00000247182 | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | SIX homeobox 1; May be involved in limb tendon and ligament development (By similarity) | 0.561 |
| SLC22A17 | STXBP6 | ENSP00000206544 | ENSP00000324302 | solute carrier family 22, member 17; Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resu [...] | syntaxin binding protein 6 (amisyn); Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.811 |
| SNAP25 | STX1A | ENSP00000254976 | ENSP00000222812 | synaptosomal-associated protein, 25kDa | syntaxin 1A (brain) | 0.929 |
| SNAP25 | STX4 | ENSP00000254976 | ENSP00000317714 | synaptosomal-associated protein, 25kDa | syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones | 0.999 |
| SNAP25 | STXBP5 | ENSP00000254976 | ENSP00000321826 | synaptosomal-associated protein, 25kDa | syntaxin binding protein 5 (tomosyn); Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Competes with STXBP1 for STX1 binding (By similarity) | 0.728 |
| SNAP25 | STXBP6 | ENSP00000254976 | ENSP00000324302 | synaptosomal-associated protein, 25kDa | syntaxin binding protein 6 (amisyn); Forms non-fusogenic complexes with SNAP25 and STX1A and may thereby modulate the formation of functional SNARE complexes and exocytosis | 0.665 |
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