| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FAM57B | MAB21L2 | ENSP00000369863 | ENSP00000324701 | family with sequence similarity 57, member B | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.402 |
| FOXE1 | MAB21L2 | ENSP00000364265 | ENSP00000324701 | forkhead box E1 (thyroid transcription factor 2); Probable transcription factor. Could be involved in thyroid gland organogenesis | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.487 |
| FOXE1 | PAX6 | ENSP00000364265 | ENSP00000368401 | forkhead box E1 (thyroid transcription factor 2); Probable transcription factor. Could be involved in thyroid gland organogenesis | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.700 |
| FOXE3 | MAB21L2 | ENSP00000334472 | ENSP00000324701 | forkhead box E3 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.472 |
| FOXE3 | PAX6 | ENSP00000334472 | ENSP00000368401 | forkhead box E3 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.930 |
| MAB21L2 | FAM57B | ENSP00000324701 | ENSP00000369863 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | family with sequence similarity 57, member B | 0.402 |
| MAB21L2 | FOXE1 | ENSP00000324701 | ENSP00000364265 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | forkhead box E1 (thyroid transcription factor 2); Probable transcription factor. Could be involved in thyroid gland organogenesis | 0.487 |
| MAB21L2 | FOXE3 | ENSP00000324701 | ENSP00000334472 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | forkhead box E3 | 0.472 |
| MAB21L2 | PAX3 | ENSP00000324701 | ENSP00000375921 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | paired box 3 | 0.447 |
| MAB21L2 | PAX6 | ENSP00000324701 | ENSP00000368401 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | 0.734 |
| MAB21L2 | PAX7 | ENSP00000324701 | ENSP00000364524 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | paired box 7; Transcription factor playing a role in myogenesis through regulation of muscle precursor cells proliferation (By similarity) | 0.439 |
| MAB21L2 | PHF11 | ENSP00000324701 | ENSP00000367570 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | PHD finger protein 11; Positive regulator of Th1-type cytokine gene expression | 0.402 |
| MAB21L2 | SRPK2 | ENSP00000324701 | ENSP00000377262 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | SRSF protein kinase 2; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and [...] | 0.461 |
| MAB21L2 | TGFB1 | ENSP00000324701 | ENSP00000221930 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.459 |
| MAB21L2 | UPP2 | ENSP00000324701 | ENSP00000387230 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates | 0.470 |
| PAX3 | MAB21L2 | ENSP00000375921 | ENSP00000324701 | paired box 3 | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.447 |
| PAX6 | FOXE1 | ENSP00000368401 | ENSP00000364265 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | forkhead box E1 (thyroid transcription factor 2); Probable transcription factor. Could be involved in thyroid gland organogenesis | 0.700 |
| PAX6 | FOXE3 | ENSP00000368401 | ENSP00000334472 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | forkhead box E3 | 0.930 |
| PAX6 | MAB21L2 | ENSP00000368401 | ENSP00000324701 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | mab-21-like 2 (C. elegans); Required for several aspects of embryonic development including normal development of the eye (By similarity) | 0.734 |
| PAX6 | TGFB1 | ENSP00000368401 | ENSP00000221930 | paired box 6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.880 |
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