node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BMP2 | BMP4 | ENSP00000368104 | ENSP00000245451 | bone morphogenetic protein 2; Induces cartilage and bone formation | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.903 |
BMP2 | FST | ENSP00000368104 | ENSP00000256759 | bone morphogenetic protein 2; Induces cartilage and bone formation | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.993 |
BMP2 | WFIKKN1 | ENSP00000368104 | ENSP00000324763 | bone morphogenetic protein 2; Induces cartilage and bone formation | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.524 |
BMP4 | BMP2 | ENSP00000245451 | ENSP00000368104 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.903 |
BMP4 | FST | ENSP00000245451 | ENSP00000256759 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.995 |
BMP4 | WFIKKN1 | ENSP00000245451 | ENSP00000324763 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.574 |
FST | BMP2 | ENSP00000256759 | ENSP00000368104 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.993 |
FST | BMP4 | ENSP00000256759 | ENSP00000245451 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.995 |
FST | GDF11 | ENSP00000256759 | ENSP00000257868 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | 0.658 |
FST | MSTN | ENSP00000256759 | ENSP00000260950 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | myostatin; Acts specifically as a negative regulator of skeletal muscle growth | 0.719 |
FST | NTSR1 | ENSP00000256759 | ENSP00000359532 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | neurotensin receptor 1 (high affinity); Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system | 0.495 |
FST | WFIKKN1 | ENSP00000256759 | ENSP00000324763 | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.748 |
GDF11 | FST | ENSP00000257868 | ENSP00000256759 | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | follistatin; Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) | 0.658 |
GDF11 | WFIKKN1 | ENSP00000257868 | ENSP00000324763 | growth differentiation factor 11; Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.809 |
IGF2BP3 | IGFBP6 | ENSP00000258729 | ENSP00000301464 | insulin-like growth factor 2 mRNA binding protein 3; RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5’-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3’-UTR of CD44 mRNA | insulin-like growth factor binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | 0.510 |
IGF2BP3 | IGFBP7 | ENSP00000258729 | ENSP00000295666 | insulin-like growth factor 2 mRNA binding protein 3; RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5’-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3’-UTR of CD44 mRNA | insulin-like growth factor binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion | 0.537 |
IGF2BP3 | WFIKKN1 | ENSP00000258729 | ENSP00000324763 | insulin-like growth factor 2 mRNA binding protein 3; RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5’-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3’-UTR of CD44 mRNA | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.541 |
IGFBP6 | IGF2BP3 | ENSP00000301464 | ENSP00000258729 | insulin-like growth factor binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | insulin-like growth factor 2 mRNA binding protein 3; RNA-binding protein that act as a regulator of mRNA translation and stability. Binds to the 5’-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binds to sequences in the 3’-UTR of CD44 mRNA | 0.510 |
IGFBP6 | IGFBP7 | ENSP00000301464 | ENSP00000295666 | insulin-like growth factor binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | insulin-like growth factor binding protein 7; Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion | 0.516 |
IGFBP6 | WFIKKN1 | ENSP00000301464 | ENSP00000324763 | insulin-like growth factor binding protein 6; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors | WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity (By similarity) | 0.520 |