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HMGCS2 HMGCS2 BDH1 BDH1 ACACA ACACA HMGCL HMGCL ACLY ACLY ACAT1 ACAT1 ACACB ACACB AACS AACS ACAT2 ACAT2 EHHADH EHHADH HMGCS1 HMGCS1
"AACS" - acetoacetyl-CoA synthetase in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
AACSacetoacetyl-CoA synthetase (672 aa)    
Predicted Functional Partners:
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase (723 aa)
      score_image   score_image score_image   0.955
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
score_image     score_image score_image   score_image   0.944
HMGCS1
3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (520 aa)
      score_image   score_image score_image   0.942
ACAT2
acetyl-CoA acetyltransferase 2 (397 aa)
      score_image   score_image score_image   0.941
ACAT1
acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism (427 aa)
      score_image   score_image score_image   0.941
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
score_image     score_image score_image   score_image   0.938
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase (508 aa)
      score_image   score_image score_image   0.934
ACLY
ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine (1101 aa)
      score_image score_image   score_image   0.931
HMGCL
3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism (325 aa)
      score_image   score_image score_image   0.929
BDH1
3-hydroxybutyrate dehydrogenase, type 1 (343 aa)
          score_image score_image   0.928
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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