node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AACS | ACACA | ENSP00000324842 | ENSP00000344789 | acetoacetyl-CoA synthetase | acetyl-CoA carboxylase alpha | 0.944 |
AACS | ACACB | ENSP00000324842 | ENSP00000341044 | acetoacetyl-CoA synthetase | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.938 |
AACS | ACAT1 | ENSP00000324842 | ENSP00000265838 | acetoacetyl-CoA synthetase | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.941 |
AACS | ACAT2 | ENSP00000324842 | ENSP00000356015 | acetoacetyl-CoA synthetase | acetyl-CoA acetyltransferase 2 | 0.941 |
AACS | ACLY | ENSP00000324842 | ENSP00000253792 | acetoacetyl-CoA synthetase | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.931 |
AACS | BDH1 | ENSP00000324842 | ENSP00000350914 | acetoacetyl-CoA synthetase | 3-hydroxybutyrate dehydrogenase, type 1 | 0.928 |
AACS | EHHADH | ENSP00000324842 | ENSP00000231887 | acetoacetyl-CoA synthetase | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.955 |
AACS | HMGCL | ENSP00000324842 | ENSP00000363614 | acetoacetyl-CoA synthetase | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.929 |
AACS | HMGCS1 | ENSP00000324842 | ENSP00000322706 | acetoacetyl-CoA synthetase | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.942 |
AACS | HMGCS2 | ENSP00000324842 | ENSP00000358414 | acetoacetyl-CoA synthetase | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.934 |
ACACA | AACS | ENSP00000344789 | ENSP00000324842 | acetyl-CoA carboxylase alpha | acetoacetyl-CoA synthetase | 0.944 |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | ACAT1 | ENSP00000344789 | ENSP00000265838 | acetyl-CoA carboxylase alpha | acetyl-CoA acetyltransferase 1; Plays a major role in ketone body metabolism | 0.980 |
ACACA | ACAT2 | ENSP00000344789 | ENSP00000356015 | acetyl-CoA carboxylase alpha | acetyl-CoA acetyltransferase 2 | 0.980 |
ACACA | ACLY | ENSP00000344789 | ENSP00000253792 | acetyl-CoA carboxylase alpha | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.983 |
ACACA | BDH1 | ENSP00000344789 | ENSP00000350914 | acetyl-CoA carboxylase alpha | 3-hydroxybutyrate dehydrogenase, type 1 | 0.414 |
ACACA | EHHADH | ENSP00000344789 | ENSP00000231887 | acetyl-CoA carboxylase alpha | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.775 |
ACACA | HMGCL | ENSP00000344789 | ENSP00000363614 | acetyl-CoA carboxylase alpha | 3-hydroxymethyl-3-methylglutaryl-CoA lyase; Key enzyme in ketogenesis (ketone body formation). Terminal step in leucine catabolism | 0.705 |
ACACA | HMGCS1 | ENSP00000344789 | ENSP00000322706 | acetyl-CoA carboxylase alpha | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.658 |
ACACA | HMGCS2 | ENSP00000344789 | ENSP00000358414 | acetyl-CoA carboxylase alpha | 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial); This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase | 0.632 |