node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CD247 | CD28 | ENSP00000354782 | ENSP00000324890 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD28 molecule | 0.965 |
CD247 | CD80 | ENSP00000354782 | ENSP00000264246 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | 0.927 |
CD247 | CD86 | ENSP00000354782 | ENSP00000332049 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | 0.923 |
CD247 | GRAP2 | ENSP00000354782 | ENSP00000339186 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.958 |
CD247 | GRB2 | ENSP00000354782 | ENSP00000339007 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.813 |
CD247 | ITK | ENSP00000354782 | ENSP00000398655 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | 0.925 |
CD247 | LCK | ENSP00000354782 | ENSP00000337825 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | lymphocyte-specific protein tyrosine kinase | 0.999 |
CD247 | VAV1 | ENSP00000354782 | ENSP00000472929 | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.937 |
CD28 | CD247 | ENSP00000324890 | ENSP00000354782 | CD28 molecule | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.965 |
CD28 | CD80 | ENSP00000324890 | ENSP00000264246 | CD28 molecule | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | 0.999 |
CD28 | CD86 | ENSP00000324890 | ENSP00000332049 | CD28 molecule | CD86 molecule; Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation | 0.990 |
CD28 | GRAP2 | ENSP00000324890 | ENSP00000339186 | CD28 molecule | GRB2-related adaptor protein 2; Interacts with SLP-76 to regulate NF-AT activation. Binds to tyrosine-phosphorylated shc | 0.994 |
CD28 | GRB2 | ENSP00000324890 | ENSP00000339007 | CD28 molecule | growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway | 0.996 |
CD28 | IGSF11 | ENSP00000324890 | ENSP00000377370 | CD28 molecule | immunoglobulin superfamily, member 11; Functions as a cell adhesion molecule through homophilic interaction. Stimulates cell growth | 0.963 |
CD28 | ITK | ENSP00000324890 | ENSP00000398655 | CD28 molecule | IL2-inducible T-cell kinase; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activ [...] | 0.970 |
CD28 | LCK | ENSP00000324890 | ENSP00000337825 | CD28 molecule | lymphocyte-specific protein tyrosine kinase | 0.994 |
CD28 | PIK3R1 | ENSP00000324890 | ENSP00000274335 | CD28 molecule | phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | 0.999 |
CD28 | VAV1 | ENSP00000324890 | ENSP00000472929 | CD28 molecule | vav 1 guanine nucleotide exchange factor; Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation | 0.994 |
CD80 | CD247 | ENSP00000264246 | ENSP00000354782 | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | CD247 molecule; Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering | 0.927 |
CD80 | CD28 | ENSP00000264246 | ENSP00000324890 | CD80 molecule; Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor | CD28 molecule | 0.999 |