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YIPF6 YIPF6 NCOA6 NCOA6 LRRC66 LRRC66 WDR5 WDR5 ZNF335 ZNF335 AR AR ZSCAN18 ZSCAN18 ASH2L ASH2L RBBP5 RBBP5 KIAA1967 KIAA1967 C11orf30 C11orf30
"ZNF335" - zinc finger protein 335 in Homo sapiens
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ZNF335zinc finger protein 335; Enhances ligand-dependent transcriptional activation by nuclear hormone receptors. This effect may be mediated by NCOA6 (1342 aa)    
Predicted Functional Partners:
KIAA1967
KIAA1967 (923 aa)
        score_image   score_image   0.930
NCOA6
nuclear receptor coactivator 6; Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. M [...] (2063 aa)
        score_image   score_image   0.814
YIPF6
Yip1 domain family, member 6 (236 aa)
            score_image   0.757
LRRC66
leucine rich repeat containing 66 (880 aa)
        score_image   score_image   0.715
WDR5
WD repeat domain 5; Contributes to histone modification. May position the N- terminus of histone H3 for efficient trimethylation at ’Lys-4’. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation (334 aa)
        score_image   score_image   0.669
RBBP5
retinoblastoma binding protein 5; In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 ’Lys-4’ methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at ’Lys-4’ of histone H3. Histone H3 ’Lys-4’ methylation represents a specific tag for epigenetic transcriptional activation (538 aa)
        score_image   score_image   0.657
ZSCAN18
zinc finger and SCAN domain containing 18; May be involved in transcriptional regulation (566 aa)
            score_image   0.625
ASH2L
ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis (628 aa)
        score_image   score_image   0.619
C11orf30
chromosome 11 open reading frame 30; Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (1322 aa)
        score_image   score_image   0.615
AR
androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 (920 aa)
        score_image   score_image   0.603
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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