node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CANX | SYNGR2 | ENSP00000247461 | ENSP00000225777 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | synaptogyrin 2 | 0.610 |
CANX | TMC8 | ENSP00000247461 | ENSP00000325561 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.685 |
RAD54L | TMC8 | ENSP00000361043 | ENSP00000325561 | RAD54-like (S. cerevisiae); Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.470 |
SLC25A25 | TMC8 | ENSP00000362159 | ENSP00000325561 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.614 |
SLC25A25 | YJEFN3 | ENSP00000362159 | ENSP00000426964 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | YjeF N-terminal domain containing 3; May play a role in spermiogenesis and oogenesis | 0.421 |
SLC30A1 | TMC8 | ENSP00000355968 | ENSP00000325561 | solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.561 |
SYNGR2 | CANX | ENSP00000225777 | ENSP00000247461 | synaptogyrin 2 | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.610 |
SYNGR2 | TK1 | ENSP00000225777 | ENSP00000301634 | synaptogyrin 2 | thymidine kinase 1, soluble | 0.681 |
SYNGR2 | TMC8 | ENSP00000225777 | ENSP00000325561 | synaptogyrin 2 | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.862 |
TK1 | SYNGR2 | ENSP00000301634 | ENSP00000225777 | thymidine kinase 1, soluble | synaptogyrin 2 | 0.681 |
TK1 | TMC8 | ENSP00000301634 | ENSP00000325561 | thymidine kinase 1, soluble | transmembrane channel-like 8; Probable ion channel (By similarity) | 0.744 |
TMC8 | CANX | ENSP00000325561 | ENSP00000247461 | transmembrane channel-like 8; Probable ion channel (By similarity) | calnexin; Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at [...] | 0.685 |
TMC8 | RAD54L | ENSP00000325561 | ENSP00000361043 | transmembrane channel-like 8; Probable ion channel (By similarity) | RAD54-like (S. cerevisiae); Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells | 0.470 |
TMC8 | SLC25A25 | ENSP00000325561 | ENSP00000362159 | transmembrane channel-like 8; Probable ion channel (By similarity) | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 | 0.614 |
TMC8 | SLC30A1 | ENSP00000325561 | ENSP00000355968 | transmembrane channel-like 8; Probable ion channel (By similarity) | solute carrier family 30 (zinc transporter), member 1; May be involved in zinc transport out of the cell | 0.561 |
TMC8 | SYNGR2 | ENSP00000325561 | ENSP00000225777 | transmembrane channel-like 8; Probable ion channel (By similarity) | synaptogyrin 2 | 0.862 |
TMC8 | TK1 | ENSP00000325561 | ENSP00000301634 | transmembrane channel-like 8; Probable ion channel (By similarity) | thymidine kinase 1, soluble | 0.744 |
TMC8 | TRADD | ENSP00000325561 | ENSP00000341268 | transmembrane channel-like 8; Probable ion channel (By similarity) | TNFRSF1A-associated via death domain; The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12- acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B | 0.810 |
TMC8 | TRAF1 | ENSP00000325561 | ENSP00000362994 | transmembrane channel-like 8; Probable ion channel (By similarity) | TNF receptor-associated factor 1; Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 | 0.581 |
TMC8 | TRAF2 | ENSP00000325561 | ENSP00000247668 | transmembrane channel-like 8; Probable ion channel (By similarity) | TNF receptor-associated factor 2; Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes ’Lys-63’- linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin- protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein level [...] | 0.915 |