node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP3B1 | RUFY1 | ENSP00000255194 | ENSP00000325594 | adaptor-related protein complex 3, beta 1 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.789 |
AP3B1 | UBC | ENSP00000255194 | ENSP00000344818 | adaptor-related protein complex 3, beta 1 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | ubiquitin C | 0.893 |
AP3B2 | RUFY1 | ENSP00000261722 | ENSP00000325594 | adaptor-related protein complex 3, beta 2 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.618 |
AP3B2 | UBC | ENSP00000261722 | ENSP00000344818 | adaptor-related protein complex 3, beta 2 subunit; Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required [...] | ubiquitin C | 0.486 |
CCT8 | RUFY1 | ENSP00000286788 | ENSP00000325594 | chaperonin containing TCP1, subunit 8 (theta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.644 |
CCT8 | UBC | ENSP00000286788 | ENSP00000344818 | chaperonin containing TCP1, subunit 8 (theta); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin | ubiquitin C | 0.996 |
EPHA3 | RUFY1 | ENSP00000337451 | ENSP00000325594 | EPH receptor A3; Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cell [...] | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.976 |
RAB14 | RUFY1 | ENSP00000362946 | ENSP00000325594 | RAB14, member RAS oncogene family; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin [...] | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.941 |
RAB14 | UBC | ENSP00000362946 | ENSP00000344818 | RAB14, member RAS oncogene family; Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N- cadherin [...] | ubiquitin C | 0.961 |
RAB4A | RAB5A | ENSP00000355651 | ENSP00000273047 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.645 |
RAB4A | RABEP1 | ENSP00000355651 | ENSP00000262477 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | 0.995 |
RAB4A | RUFY1 | ENSP00000355651 | ENSP00000325594 | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.966 |
RAB5A | RAB4A | ENSP00000273047 | ENSP00000355651 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.645 |
RAB5A | RABEP1 | ENSP00000273047 | ENSP00000262477 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | 0.999 |
RAB5A | RUFY1 | ENSP00000273047 | ENSP00000325594 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.942 |
RAB5A | UBC | ENSP00000273047 | ENSP00000344818 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | ubiquitin C | 0.951 |
RAB5A | VPS26A | ENSP00000273047 | ENSP00000263559 | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) | 0.517 |
RABEP1 | RAB4A | ENSP00000262477 | ENSP00000355651 | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | RAB4A, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) | 0.995 |
RABEP1 | RAB5A | ENSP00000262477 | ENSP00000273047 | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | RAB5A, member RAS oncogene family; Required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension | 0.999 |
RABEP1 | RUFY1 | ENSP00000262477 | ENSP00000325594 | rabaptin, RAB GTPase binding effector protein 1; Rab effector protein acting as linker between gamma- adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A | RUN and FYVE domain containing 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking | 0.745 |