node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DDX25 | PGK2 | ENSP00000263576 | ENSP00000305995 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | phosphoglycerate kinase 2 | 0.466 |
DDX25 | PRM1 | ENSP00000263576 | ENSP00000310515 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.416 |
DDX25 | PRM2 | ENSP00000263576 | ENSP00000241808 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.450 |
DDX25 | TNP2 | ENSP00000263576 | ENSP00000325738 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.620 |
HIST1H1T | PGK2 | ENSP00000341214 | ENSP00000305995 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | phosphoglycerate kinase 2 | 0.562 |
HIST1H1T | PRM1 | ENSP00000341214 | ENSP00000310515 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.637 |
HIST1H1T | PRM2 | ENSP00000341214 | ENSP00000241808 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.633 |
HIST1H1T | SMCP | ENSP00000341214 | ENSP00000357754 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.422 |
HIST1H1T | TNP1 | ENSP00000341214 | ENSP00000236979 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.700 |
HIST1H1T | TNP2 | ENSP00000341214 | ENSP00000325738 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.645 |
KPNA3 | TNP1 | ENSP00000261667 | ENSP00000236979 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.610 |
KPNA3 | TNP2 | ENSP00000261667 | ENSP00000325738 | karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.755 |
PARP2 | TNP2 | ENSP00000250416 | ENSP00000325738 | poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks | transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) | 0.617 |
PGK2 | DDX25 | ENSP00000305995 | ENSP00000263576 | phosphoglycerate kinase 2 | DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) | 0.466 |
PGK2 | HIST1H1T | ENSP00000305995 | ENSP00000341214 | phosphoglycerate kinase 2 | histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures | 0.562 |
PGK2 | PRM1 | ENSP00000305995 | ENSP00000310515 | phosphoglycerate kinase 2 | protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.725 |
PGK2 | PRM2 | ENSP00000305995 | ENSP00000241808 | phosphoglycerate kinase 2 | protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex | 0.725 |
PGK2 | PRM3 | ENSP00000305995 | ENSP00000325638 | phosphoglycerate kinase 2 | protamine 3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) | 0.407 |
PGK2 | SMCP | ENSP00000305995 | ENSP00000357754 | phosphoglycerate kinase 2 | sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.416 |
PGK2 | TNP1 | ENSP00000305995 | ENSP00000236979 | phosphoglycerate kinase 2 | transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins | 0.631 |