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KPNA3 KPNA3 PARP2 PARP2 SMCP SMCP TNP1 TNP1 TNP2 TNP2 PRM3 PRM3 HIST1H1T HIST1H1T PRM1 PRM1 PRM2 PRM2 PGK2 PGK2 DDX25 DDX25
"TNP2" - transition protein 2 (during histone to protamine replacement) in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
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experimentally determined
Predicted Interactions
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textmining
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protein homology
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Score
TNP2transition protein 2 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity) (138 aa)    
Predicted Functional Partners:
PRM2
protamine 2; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (102 aa)
            score_image   0.878
PRM1
protamine 1; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) (51 aa)
            score_image   0.870
TNP1
transition protein 1 (during histone to protamine replacement); In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (55 aa)
            score_image   0.870
KPNA3
karyopherin alpha 3 (importin alpha 4); Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alph [...] (521 aa)
            score_image   0.755
SMCP
sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) (116 aa)
            score_image   0.725
PRM3
protamine 3; Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex (By similarity) (103 aa)
            score_image   0.720
PGK2
phosphoglycerate kinase 2 (417 aa)
            score_image   0.691
HIST1H1T
histone cluster 1, H1t; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures (207 aa)
            score_image   0.645
DDX25
DEAD (Asp-Glu-Ala-Asp) box helicase 25; ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity) (483 aa)
            score_image   0.620
PARP2
poly (ADP-ribose) polymerase 2; Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (583 aa)
        score_image   score_image   0.617
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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