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STRINGSTRING
CTTNBP2NL CTTNBP2NL PDCD10 PDCD10 STRN4 STRN4 PPP2CA PPP2CA STRN3 STRN3 STK25 STK25 STRIP1 STRIP1 MOB4 MOB4 STRN STRN FGFR1OP2 FGFR1OP2 SLMAP SLMAP
"STK25" - serine/threonine kinase 25 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
STK25serine/threonine kinase 25; Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration (426 aa)    
Predicted Functional Partners:
PDCD10
programmed cell death 10; Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and MST4 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity) (212 aa)
        score_image   score_image   0.999
STRN
striatin, calmodulin binding protein; Calmodulin-binding protein which may function as scaffolding or signaling protein and may play a role in dendritic Ca(2+) signaling (780 aa)
        score_image   score_image   0.999
STRIP1
striatin interacting protein 1; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics and cell shape (837 aa)
        score_image   score_image   0.999
CTTNBP2NL
CTTNBP2 N-terminal like (639 aa)
        score_image   score_image   0.999
STRN3
striatin, calmodulin binding protein 3; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (797 aa)
        score_image   score_image   0.999
SLMAP
sarcolemma associated protein (811 aa)
        score_image   score_image   0.999
STRN4
striatin, calmodulin binding protein 4; Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein (760 aa)
        score_image   score_image   0.999
FGFR1OP2
FGFR1 oncogene partner 2; May be involved in wound healing pathway (By similarity) (253 aa)
        score_image   score_image   0.999
PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme; PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at ’Ser-259’ (309 aa)
      score_image score_image   score_image   0.999
MOB4
MOB family member 4, phocein; May play a role in membrane trafficking, specifically in membrane budding reactions (By similarity) (225 aa)
        score_image   score_image   0.999
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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