DIRAS1 protein (Homo sapiens) - STRING network view

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DIRAS1

DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form (198 aa)

Predicted Functional Partners:

PIK3CB

0.963

LRRC24

0.716

MAP3K19

0.709

MAP3K3

0.709

MAP3K2

0.709

CPNE9

0.701

SPATA13

0.691

NCF4

0.670

SH3PXD2A

0.670

SH3PXD2B

0.670

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CPNE9	DIRAS1	ENSP00000373343	ENSP00000325836	copine family member IX; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	0.701
CPNE9	LRRC24	ENSP00000373343	ENSP00000434849	copine family member IX; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	leucine rich repeat containing 24	0.630
DIRAS1	CPNE9	ENSP00000325836	ENSP00000373343	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	copine family member IX; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	0.701
DIRAS1	LRRC24	ENSP00000325836	ENSP00000434849	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	leucine rich repeat containing 24	0.716
DIRAS1	MAP3K19	ENSP00000325836	ENSP00000365005	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	mitogen-activated protein kinase kinase kinase 19	0.709
DIRAS1	MAP3K2	ENSP00000325836	ENSP00000343463	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics	0.709
DIRAS1	MAP3K3	ENSP00000325836	ENSP00000354927	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators	0.709
DIRAS1	NCF4	ENSP00000325836	ENSP00000380334	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex	0.670
DIRAS1	PIK3CB	ENSP00000325836	ENSP00000289153	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G- [...]	0.963
DIRAS1	SH3PXD2A	ENSP00000325836	ENSP00000348215	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide	0.670
DIRAS1	SH3PXD2B	ENSP00000325836	ENSP00000309714	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity)	0.670
DIRAS1	SPATA13	ENSP00000325836	ENSP00000371542	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	spermatogenesis associated 13	0.691
LRRC24	CPNE9	ENSP00000434849	ENSP00000373343	leucine rich repeat containing 24	copine family member IX; May function in membrane trafficking. Exhibits calcium- dependent phospholipid binding properties (By similarity)	0.630
LRRC24	DIRAS1	ENSP00000434849	ENSP00000325836	leucine rich repeat containing 24	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	0.716
MAP3K19	DIRAS1	ENSP00000365005	ENSP00000325836	mitogen-activated protein kinase kinase kinase 19	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	0.709
MAP3K19	NCF4	ENSP00000365005	ENSP00000380334	mitogen-activated protein kinase kinase kinase 19	neutrophil cytosolic factor 4, 40kDa; Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex	0.535
MAP3K19	SH3PXD2A	ENSP00000365005	ENSP00000348215	mitogen-activated protein kinase kinase kinase 19	SH3 and PX domains 2A; Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide	0.535
MAP3K19	SH3PXD2B	ENSP00000365005	ENSP00000309714	mitogen-activated protein kinase kinase kinase 19	SH3 and PX domains 2B; Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity)	0.535
MAP3K2	DIRAS1	ENSP00000343463	ENSP00000325836	mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics	DIRAS family, GTP-binding RAS-like 1; Displays low GTPase activity and exist predominantly in the GTP-bound form	0.709
MAP3K2	MAP3K3	ENSP00000343463	ENSP00000354927	mitogen-activated protein kinase kinase kinase 2; Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics	mitogen-activated protein kinase kinase kinase 3; Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators	0.652

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