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RNF133 RNF133 UBE2U UBE2U RFWD3 RFWD3 RNF113B RNF113B RNF181 RNF181 RNF166 RNF166 UBC UBC RNF41 RNF41 ARL9 ARL9 RNF126 RNF126 MKRN3 MKRN3
"RNF166" - ring finger protein 166 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
RNF166ring finger protein 166 (237 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
         score_image   score_image   0.647
RNF181
ring finger protein 181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (153 aa)
             score_image   0.596
RFWD3
ring finger and WD repeat domain 3; E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA dam [...] (774 aa)
             score_image   0.579
UBE2U
ubiquitin-conjugating enzyme E2U (putative); Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) (226 aa)
         score_image   score_image   0.574
RNF133
ring finger protein 133; Has E3 ubiquitin-protein ligase activity (By similarity) (376 aa)
             score_image   0.536
RNF113B
ring finger protein 113B (322 aa)
             score_image   0.517
RNF126
ring finger protein 126 (311 aa)
             score_image   0.512
ARL9
ADP-ribosylation factor-like 9 (187 aa)
             score_image   0.472
RNF41
ring finger protein 41; Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 and Negatively regulates MYD88-dependent production of proinflammatory cytokines but can promote TRIF-dependent production of type I interferon. Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL- 3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By s [...] (317 aa)
         score_image       0.461
MKRN3
makorin ring finger protein 3; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity) (507 aa)
         score_image       0.461
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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