ZNF454 protein (Homo sapiens) - STRING network view

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ZNF454

zinc finger protein 454; May be involved in transcriptional regulation (522 aa)

Predicted Functional Partners:

UQCRFS1

0.673

ABCD3

0.658

SRSF3

0.644

VDAC2

0.644

CCDC129

0.567

XRN1

0.543

TKTL2

0.503

KDM2A

0.501

FBXL19

0.501

KDM2B

0.501

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCD3	ZNF454	ENSP00000359233	ENSP00000326249	ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity	zinc finger protein 454; May be involved in transcriptional regulation	0.658
CCDC129	TKTL2	ENSP00000384416	ENSP00000280605	coiled-coil domain containing 129	transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis	0.418
CCDC129	ZNF454	ENSP00000384416	ENSP00000326249	coiled-coil domain containing 129	zinc finger protein 454; May be involved in transcriptional regulation	0.567
FBXL19	ZNF454	ENSP00000369666	ENSP00000326249	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	zinc finger protein 454; May be involved in transcriptional regulation	0.501
KDM2A	ZNF454	ENSP00000432786	ENSP00000326249	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	zinc finger protein 454; May be involved in transcriptional regulation	0.501
KDM2B	ZNF454	ENSP00000366271	ENSP00000326249	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	zinc finger protein 454; May be involved in transcriptional regulation	0.501
SRSF3	UQCRFS1	ENSP00000362820	ENSP00000306397	serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	0.586
SRSF3	ZNF454	ENSP00000362820	ENSP00000326249	serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation	zinc finger protein 454; May be involved in transcriptional regulation	0.644
TKTL2	CCDC129	ENSP00000280605	ENSP00000384416	transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis	coiled-coil domain containing 129	0.418
TKTL2	ZNF454	ENSP00000280605	ENSP00000326249	transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis	zinc finger protein 454; May be involved in transcriptional regulation	0.503
UQCRFS1	SRSF3	ENSP00000306397	ENSP00000362820	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation	0.586
UQCRFS1	ZNF454	ENSP00000306397	ENSP00000326249	ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	zinc finger protein 454; May be involved in transcriptional regulation	0.673
VDAC2	ZNF454	ENSP00000361635	ENSP00000326249	voltage-dependent anion channel 2; Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation- selective	zinc finger protein 454; May be involved in transcriptional regulation	0.644
XRN1	ZNF454	ENSP00000264951	ENSP00000326249	5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS)	zinc finger protein 454; May be involved in transcriptional regulation	0.543
ZNF454	ABCD3	ENSP00000326249	ENSP00000359233	zinc finger protein 454; May be involved in transcriptional regulation	ATP-binding cassette, sub-family D (ALD), member 3; Probable transporter. The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity	0.658
ZNF454	CCDC129	ENSP00000326249	ENSP00000384416	zinc finger protein 454; May be involved in transcriptional regulation	coiled-coil domain containing 129	0.567
ZNF454	FBXL19	ENSP00000326249	ENSP00000369666	zinc finger protein 454; May be involved in transcriptional regulation	F-box and leucine-rich repeat protein 19; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity)	0.501
ZNF454	KDM2A	ENSP00000326249	ENSP00000432786	zinc finger protein 454; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2A; Histone demethylase that specifically demethylates ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys- 36’. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at [...]	0.501
ZNF454	KDM2B	ENSP00000326249	ENSP00000366271	zinc finger protein 454; May be involved in transcriptional regulation	lysine (K)-specific demethylase 2B; Histone demethylase that demethylates ’Lys-4’ and ’Lys- 36’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 ’Lys-4’ and dimethylated H3 ’Lys-36’ residue while it has weak or no activity for mono- and tri-methylated H3 ’Lys-36’. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin [...]	0.501
ZNF454	SRSF3	ENSP00000326249	ENSP00000362820	zinc finger protein 454; May be involved in transcriptional regulation	serine/arginine-rich splicing factor 3; May be involved in RNA processing in relation with cellular proliferation and/or maturation	0.644

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