| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATG12 | ATG16L2 | ENSP00000425107 | ENSP00000326340 | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | 0.512 |
| ATG12 | ATG5 | ENSP00000425107 | ENSP00000343313 | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | 0.999 |
| ATG12 | ATG9A | ENSP00000425107 | ENSP00000355173 | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | autophagy related 9A | 0.873 |
| ATG16L2 | ATG12 | ENSP00000326340 | ENSP00000425107 | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | 0.512 |
| ATG16L2 | ATG5 | ENSP00000326340 | ENSP00000343313 | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | 0.995 |
| ATG16L2 | ATG9A | ENSP00000326340 | ENSP00000355173 | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | autophagy related 9A | 0.555 |
| ATG16L2 | CHUK | ENSP00000326340 | ENSP00000359424 | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | 0.576 |
| ATG16L2 | TMEM86A | ENSP00000326340 | ENSP00000280734 | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | transmembrane protein 86A | 0.450 |
| ATG5 | ATG12 | ENSP00000343313 | ENSP00000425107 | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | 0.999 |
| ATG5 | ATG16L2 | ENSP00000343313 | ENSP00000326340 | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | 0.995 |
| ATG5 | ATG9A | ENSP00000343313 | ENSP00000355173 | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | autophagy related 9A | 0.869 |
| ATG9A | ATG12 | ENSP00000355173 | ENSP00000425107 | autophagy related 9A | autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] | 0.873 |
| ATG9A | ATG16L2 | ENSP00000355173 | ENSP00000326340 | autophagy related 9A | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | 0.555 |
| ATG9A | ATG5 | ENSP00000355173 | ENSP00000343313 | autophagy related 9A | autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) | 0.869 |
| CHUK | ATG16L2 | ENSP00000359424 | ENSP00000326340 | conserved helix-loop-helix ubiquitous kinase; Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus [...] | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | 0.576 |
| TMEM86A | ATG16L2 | ENSP00000280734 | ENSP00000326340 | transmembrane protein 86A | autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) | 0.450 |
Share
