| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANGPT2 | DLL4 | ENSP00000314897 | ENSP00000249749 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | 0.536 |
| ANGPT2 | FOXC2 | ENSP00000314897 | ENSP00000326371 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | 0.877 |
| ANGPT2 | PROX1 | ENSP00000314897 | ENSP00000261454 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | prospero homeobox 1; May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity) | 0.855 |
| ANGPT2 | VEGFA | ENSP00000314897 | ENSP00000361125 | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | vascular endothelial growth factor A | 0.982 |
| BMP2 | FOXC2 | ENSP00000368104 | ENSP00000326371 | bone morphogenetic protein 2; Induces cartilage and bone formation | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | 0.859 |
| BMP2 | INS | ENSP00000368104 | ENSP00000250971 | bone morphogenetic protein 2; Induces cartilage and bone formation | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.502 |
| BMP2 | MYOD1 | ENSP00000368104 | ENSP00000250003 | bone morphogenetic protein 2; Induces cartilage and bone formation | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.909 |
| BMP2 | PAX3 | ENSP00000368104 | ENSP00000375921 | bone morphogenetic protein 2; Induces cartilage and bone formation | paired box 3 | 0.675 |
| BMP2 | SHH | ENSP00000368104 | ENSP00000297261 | bone morphogenetic protein 2; Induces cartilage and bone formation | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.992 |
| BMP2 | VEGFA | ENSP00000368104 | ENSP00000361125 | bone morphogenetic protein 2; Induces cartilage and bone formation | vascular endothelial growth factor A | 0.904 |
| DLL4 | ANGPT2 | ENSP00000249749 | ENSP00000314897 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | 0.536 |
| DLL4 | FOXC2 | ENSP00000249749 | ENSP00000326371 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | 0.896 |
| DLL4 | SHH | ENSP00000249749 | ENSP00000297261 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.505 |
| DLL4 | VEGFA | ENSP00000249749 | ENSP00000361125 | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | vascular endothelial growth factor A | 0.926 |
| FOXC2 | ANGPT2 | ENSP00000326371 | ENSP00000314897 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | angiopoietin 2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal | 0.877 |
| FOXC2 | BMP2 | ENSP00000326371 | ENSP00000368104 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | bone morphogenetic protein 2; Induces cartilage and bone formation | 0.859 |
| FOXC2 | DLL4 | ENSP00000326371 | ENSP00000249749 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | delta-like 4 (Drosophila); Plays a role in the Notch signaling pathway. Activates Notch-1 and Notch-4 (By similarity) | 0.896 |
| FOXC2 | INS | ENSP00000326371 | ENSP00000250971 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver (By similarity) | 0.860 |
| FOXC2 | ITGB3 | ENSP00000326371 | ENSP00000262017 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61); Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. [...] | 0.900 |
| FOXC2 | MYOD1 | ENSP00000326371 | ENSP00000250003 | forkhead box C2 (MFH-1, mesenchyme forkhead 1); Transcriptional activator. Might be involved in the formation of special mesenchymal tissues | myogenic differentiation 1; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity) | 0.861 |
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