node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSBG2 | CLEC1A | ENSP00000252669 | ENSP00000326407 | acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis | C-type lectin domain family 1, member A | 0.606 |
ASGR1 | CLEC1A | ENSP00000269299 | ENSP00000326407 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | C-type lectin domain family 1, member A | 0.564 |
ASGR1 | PDPN | ENSP00000269299 | ENSP00000294489 | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | podoplanin; May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels | 0.515 |
CLEC1A | ACSBG2 | ENSP00000326407 | ENSP00000252669 | C-type lectin domain family 1, member A | acyl-CoA synthetase bubblegum family member 2; Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis | 0.606 |
CLEC1A | ASGR1 | ENSP00000326407 | ENSP00000269299 | C-type lectin domain family 1, member A | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | 0.564 |
CLEC1A | CLEC4E | ENSP00000326407 | ENSP00000299663 | C-type lectin domain family 1, member A | C-type lectin domain family 4, member E; C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6’-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc recep [...] | 0.577 |
CLEC1A | CLECL1 | ENSP00000326407 | ENSP00000331766 | C-type lectin domain family 1, member A | C-type lectin-like 1; May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response | 0.515 |
CLEC1A | KLRC4 | ENSP00000326407 | ENSP00000310216 | C-type lectin domain family 1, member A | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | 0.560 |
CLEC1A | KLRG1 | ENSP00000326407 | ENSP00000349477 | C-type lectin domain family 1, member A | killer cell lectin-like receptor subfamily G, member 1; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells | 0.668 |
CLEC1A | MAMDC2 | ENSP00000326407 | ENSP00000366387 | C-type lectin domain family 1, member A | MAM domain containing 2 | 0.507 |
CLEC1A | PDPN | ENSP00000326407 | ENSP00000294489 | C-type lectin domain family 1, member A | podoplanin; May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels | 0.489 |
CLEC1A | REG1A | ENSP00000326407 | ENSP00000233735 | C-type lectin domain family 1, member A | regenerating islet-derived 1 alpha; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | 0.561 |
CLEC1A | REG1B | ENSP00000326407 | ENSP00000303206 | C-type lectin domain family 1, member A | regenerating islet-derived 1 beta; Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration | 0.680 |
CLEC4E | CLEC1A | ENSP00000299663 | ENSP00000326407 | C-type lectin domain family 4, member E; C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6’-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc recep [...] | C-type lectin domain family 1, member A | 0.577 |
CLECL1 | CLEC1A | ENSP00000331766 | ENSP00000326407 | C-type lectin-like 1; May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3- induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response | C-type lectin domain family 1, member A | 0.515 |
KLRC4 | CLEC1A | ENSP00000310216 | ENSP00000326407 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | C-type lectin domain family 1, member A | 0.560 |
KLRC4 | PDPN | ENSP00000310216 | ENSP00000294489 | killer cell lectin-like receptor subfamily C, member 4; May play a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells | podoplanin; May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels | 0.414 |
KLRG1 | CLEC1A | ENSP00000349477 | ENSP00000326407 | killer cell lectin-like receptor subfamily G, member 1; Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells | C-type lectin domain family 1, member A | 0.668 |
MAMDC2 | CLEC1A | ENSP00000366387 | ENSP00000326407 | MAM domain containing 2 | C-type lectin domain family 1, member A | 0.507 |
PDPN | ASGR1 | ENSP00000294489 | ENSP00000269299 | podoplanin; May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels | asialoglycoprotein receptor 1; Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface | 0.515 |