node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD1 | CABLES1 | ENSP00000326491 | ENSP00000256925 | abhydrolase domain containing 1 | Cdk5 and Abl enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | 0.614 |
ABHD1 | CABLES2 | ENSP00000326491 | ENSP00000279101 | abhydrolase domain containing 1 | Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | 0.588 |
ABHD1 | FGF19 | ENSP00000326491 | ENSP00000294312 | abhydrolase domain containing 1 | fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4 | 0.686 |
ABHD1 | OSBPL1A | ENSP00000326491 | ENSP00000320291 | abhydrolase domain containing 1 | oxysterol binding protein-like 1A; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A | 0.636 |
ABHD1 | OSBPL2 | ENSP00000326491 | ENSP00000316649 | abhydrolase domain containing 1 | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.597 |
ABHD1 | OSBPL3 | ENSP00000326491 | ENSP00000315410 | abhydrolase domain containing 1 | oxysterol binding protein-like 3 | 0.453 |
ABHD1 | PREB | ENSP00000326491 | ENSP00000260643 | abhydrolase domain containing 1 | prolactin regulatory element binding; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER | 0.747 |
ABHD1 | SNTG1 | ENSP00000326491 | ENSP00000429276 | abhydrolase domain containing 1 | syntrophin, gamma 1; Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity). May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation | 0.458 |
ABHD1 | USP26 | ENSP00000326491 | ENSP00000359869 | abhydrolase domain containing 1 | ubiquitin specific peptidase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway | 0.510 |
ABHD1 | YIPF2 | ENSP00000326491 | ENSP00000253031 | abhydrolase domain containing 1 | Yip1 domain family, member 2 | 0.439 |
CABLES1 | ABHD1 | ENSP00000256925 | ENSP00000326491 | Cdk5 and Abl enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | abhydrolase domain containing 1 | 0.614 |
CABLES1 | OSBPL1A | ENSP00000256925 | ENSP00000320291 | Cdk5 and Abl enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | oxysterol binding protein-like 1A; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A | 0.507 |
CABLES1 | OSBPL2 | ENSP00000256925 | ENSP00000316649 | Cdk5 and Abl enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.485 |
CABLES2 | ABHD1 | ENSP00000279101 | ENSP00000326491 | Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | abhydrolase domain containing 1 | 0.588 |
CABLES2 | OSBPL1A | ENSP00000279101 | ENSP00000320291 | Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | oxysterol binding protein-like 1A; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A | 0.485 |
CABLES2 | OSBPL2 | ENSP00000279101 | ENSP00000316649 | Cdk5 and Abl enzyme substrate 2; Unknown. Probably involved in G1-S cell cycle transition | oxysterol binding protein-like 2; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate | 0.485 |
FGF19 | ABHD1 | ENSP00000294312 | ENSP00000326491 | fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4 | abhydrolase domain containing 1 | 0.686 |
FGF19 | PREB | ENSP00000294312 | ENSP00000260643 | fibroblast growth factor 19; Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4 | prolactin regulatory element binding; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER | 0.520 |
OSBPL1A | ABHD1 | ENSP00000320291 | ENSP00000326491 | oxysterol binding protein-like 1A; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A | abhydrolase domain containing 1 | 0.636 |
OSBPL1A | CABLES1 | ENSP00000320291 | ENSP00000256925 | oxysterol binding protein-like 1A; Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3- phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A | Cdk5 and Abl enzyme substrate 1; Cyclin-dependent kinase binding protein. Enhances cyclin-dependent kinase tyrosine phosphorylation by nonreceptor tyrosine kinases, such as that of CDK5 by activated ABL1, which leads to increased CDK5 activity and is critical for neuronal development, and that of CDK2 by WEE1, which leads to decreased CDK2 activity and growth inhibition. Positively affects neuronal outgrowth. Plays a role as a regulator for p53/p73-induced cell death (By similarity) | 0.507 |