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STRINGSTRING
C9orf72 C9orf72 EED EED METTL4 METTL4 SUMO2 SUMO2 SMCHD1 SMCHD1 UBC UBC LPIN2 LPIN2 SLC30A6 SLC30A6 ZFP161 ZFP161 EPB41L3 EPB41L3 ENSG00000157654 ENSG00000157654
"SMCHD1" - structural maintenance of chromosomes flexible hinge domain containing 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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SMCHD1structural maintenance of chromosomes flexible hinge domain containing 1; Required for maintenance of X inactivation in females and hypermethylation of CpG islands associated with inactive X. Involved in a pathway that mediates the methylation of a subset of CpG islands slowly and requires the de novo methyltransferase DNMT3B (By similarity). Required for DUX4 silencing in somatic cells (2005 aa)    
Predicted Functional Partners:
UBC
ubiquitin C (685 aa)
        score_image       0.889
SUMO2
SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae); Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduc [...] (95 aa)
        score_image   score_image   0.784
LPIN2
lipin 2; Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism (By similarity) (896 aa)
            score_image   0.712
SLC30A6
solute carrier family 30 (zinc transporter), member 6; Zinc-efflux transporter which allocates the cytoplasmic zinc to the trans-Golgi network (TGN) as well as the vesicular compartment (By similarity) (501 aa)
            score_image   0.630
EPB41L3
erythrocyte membrane protein band 4.1-like 3; Critical growth regulator in the pathogenesis of meningiomas (1087 aa)
            score_image   0.565
C9orf72
chromosome 9 open reading frame 72 (481 aa)
            score_image   0.489
ZFP161
zinc finger protein 161 homolog (mouse); Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters (449 aa)
            score_image   0.479
ENSG00000157654
PALM2-AKAP2 readthrough (1103 aa)
            score_image   0.472
EED
embryonic ectoderm development; Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates ’Lys-9’ and ’Lys-27’ of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes ’Lys-26’ trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 ’Lys-27’, whereas H3 ’Lys-27’ recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby link [...] (441 aa)
        score_image   score_image   0.423
METTL4
methyltransferase like 4; Probable methyltransferase (By similarity) (472 aa)
            score_image   0.418
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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