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STRINGSTRING
TMEM72 TMEM72 ACTB ACTB TP63 TP63 SPATS2 SPATS2 POTEF POTEF NRAS NRAS SRPK1 SRPK1
"SPATS2" - spermatogenesis associated, serine-rich 2 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
SPATS2spermatogenesis associated, serine-rich 2 (545 aa)    
Predicted Functional Partners:
NRAS
neuroblastoma RAS viral (v-ras) oncogene homolog; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)
        score_image       0.644
POTEF
POTE ankyrin domain family, member F (1075 aa)
            score_image   0.610
ACTB
actin, beta (375 aa)
            score_image   0.608
TP63
tumor protein p63; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity) (680 aa)
            score_image   0.589
SRPK1
SRSF protein kinase 1; Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Can influence additional steps of mRNA maturation, as well as other cellular activiti [...] (655 aa)
        score_image       0.461
TMEM72
transmembrane protein 72 (275 aa)
            score_image   0.456
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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