node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2A1 | ORMDL1 | ENSP00000349595 | ENSP00000326869 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | 0.632 |
ATP2A1 | UBC | ENSP00000349595 | ENSP00000344818 | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction | ubiquitin C | 0.857 |
CERKL | ORM2 | ENSP00000341159 | ENSP00000394936 | ceramide kinase-like | orosomucoid 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction | 0.590 |
CERKL | ORMDL1 | ENSP00000341159 | ENSP00000326869 | ceramide kinase-like | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | 0.658 |
CERKL | SPTLC1 | ENSP00000341159 | ENSP00000262554 | ceramide kinase-like | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] | 0.616 |
CERKL | SPTLC2 | ENSP00000341159 | ENSP00000216484 | ceramide kinase-like | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.655 |
CERKL | SPTLC3 | ENSP00000341159 | ENSP00000381968 | ceramide kinase-like | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.666 |
DDOST | ORMDL1 | ENSP00000364188 | ENSP00000326869 | dolichyl-diphosphooligosaccharide--protein glycosyltransferase; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | 0.503 |
DDOST | UBC | ENSP00000364188 | ENSP00000344818 | dolichyl-diphosphooligosaccharide--protein glycosyltransferase; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | ubiquitin C | 0.973 |
ORM2 | CERKL | ENSP00000394936 | ENSP00000341159 | orosomucoid 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction | ceramide kinase-like | 0.590 |
ORM2 | ORMDL1 | ENSP00000394936 | ENSP00000326869 | orosomucoid 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | 0.868 |
ORMDL1 | ATP2A1 | ENSP00000326869 | ENSP00000349595 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction | 0.632 |
ORMDL1 | CERKL | ENSP00000326869 | ENSP00000341159 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | ceramide kinase-like | 0.658 |
ORMDL1 | DDOST | ENSP00000326869 | ENSP00000364188 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | dolichyl-diphosphooligosaccharide--protein glycosyltransferase; Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains | 0.503 |
ORMDL1 | ORM2 | ENSP00000326869 | ENSP00000394936 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | orosomucoid 2; Functions as transport protein in the blood stream. Binds various hydrophobic ligands in the interior of its beta- barrel domain. Also binds synthetic drugs and influences their distribution and availability. Appears to function in modulating the activity of the immune system during the acute-phase reaction | 0.868 |
ORMDL1 | PIGO | ENSP00000326869 | ENSP00000339382 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | phosphatidylinositol glycan anchor biosynthesis, class O; Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond (By similarity) | 0.570 |
ORMDL1 | SPTLC1 | ENSP00000326869 | ENSP00000262554 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | serine palmitoyltransferase, long chain base subunit 1; Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1- SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isoz [...] | 0.777 |
ORMDL1 | SPTLC2 | ENSP00000326869 | ENSP00000216484 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | serine palmitoyltransferase, long chain base subunit 2; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate | 0.708 |
ORMDL1 | SPTLC3 | ENSP00000326869 | ENSP00000381968 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | serine palmitoyltransferase, long chain base subunit 3; Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, while the SPTLC1-SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference | 0.667 |
ORMDL1 | UBC | ENSP00000326869 | ENSP00000344818 | ORM1-like 1 (S. cerevisiae); Negative regulator of sphingolipid synthesis | ubiquitin C | 0.725 |