MDH2 protein (Homo sapiens) - STRING network view

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Score

MDH2

malate dehydrogenase 2, NAD (mitochondrial) (338 aa)

Predicted Functional Partners:

CS

0.996

GOT2

0.995

FH

0.994

MDH1

0.987

PC

0.979

ACLY

0.978

GOT1

0.968

ME3

0.967

ME1

0.963

ME2

0.962

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	CS	ENSP00000253792	ENSP00000342056	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	citrate synthase	0.955
ACLY	FH	ENSP00000253792	ENSP00000355518	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	fumarate hydratase; Also acts as a tumor suppressor	0.941
ACLY	GOT1	ENSP00000253792	ENSP00000359539	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...]	0.597
ACLY	GOT2	ENSP00000253792	ENSP00000245206	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids	0.593
ACLY	MDH1	ENSP00000253792	ENSP00000438144	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	malate dehydrogenase 1, NAD (soluble)	0.977
ACLY	MDH2	ENSP00000253792	ENSP00000327070	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	malate dehydrogenase 2, NAD (mitochondrial)	0.978
ACLY	ME1	ENSP00000253792	ENSP00000358719	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	malic enzyme 1, NADP(+)-dependent, cytosolic	0.878
ACLY	ME2	ENSP00000253792	ENSP00000321070	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.868
ACLY	ME3	ENSP00000253792	ENSP00000352657	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.890
ACLY	PC	ENSP00000253792	ENSP00000377527	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.872
CS	ACLY	ENSP00000342056	ENSP00000253792	citrate synthase	ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine	0.955
CS	FH	ENSP00000342056	ENSP00000355518	citrate synthase	fumarate hydratase; Also acts as a tumor suppressor	0.985
CS	GOT1	ENSP00000342056	ENSP00000359539	citrate synthase	glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1); Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is conve [...]	0.890
CS	GOT2	ENSP00000342056	ENSP00000245206	citrate synthase	glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2); Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids	0.940
CS	MDH1	ENSP00000342056	ENSP00000438144	citrate synthase	malate dehydrogenase 1, NAD (soluble)	0.987
CS	MDH2	ENSP00000342056	ENSP00000327070	citrate synthase	malate dehydrogenase 2, NAD (mitochondrial)	0.996
CS	ME1	ENSP00000342056	ENSP00000358719	citrate synthase	malic enzyme 1, NADP(+)-dependent, cytosolic	0.895
CS	ME2	ENSP00000342056	ENSP00000321070	citrate synthase	malic enzyme 2, NAD(+)-dependent, mitochondrial	0.885
CS	ME3	ENSP00000342056	ENSP00000352657	citrate synthase	malic enzyme 3, NADP(+)-dependent, mitochondrial	0.904
CS	PC	ENSP00000342056	ENSP00000377527	citrate synthase	pyruvate carboxylase; Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate	0.985

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