node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR1A | AZI1 | ENSP00000358921 | ENSP00000393583 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | 0.900 |
ACTR1A | BBS4 | ENSP00000358921 | ENSP00000268057 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | Bardet-Biedl syndrome 4; May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane [...] | 0.420 |
ACTR1A | CEP290 | ENSP00000358921 | ENSP00000448012 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | centrosomal protein 290kDa; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes | 0.900 |
ACTR1A | CEP72 | ENSP00000358921 | ENSP00000264935 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) | 0.900 |
ACTR1A | DCTN2 | ENSP00000358921 | ENSP00000408910 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development | 0.999 |
ACTR1A | OFD1 | ENSP00000358921 | ENSP00000344314 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | 0.900 |
ACTR1A | PCM1 | ENSP00000358921 | ENSP00000327077 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | pericentriolar material 1; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia | 0.959 |
ACTR1A | PCNT | ENSP00000358921 | ENSP00000352572 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.900 |
ACTR1A | RAB8A | ENSP00000358921 | ENSP00000300935 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | RAB8A, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization | 0.928 |
ACTR1A | UBC | ENSP00000358921 | ENSP00000344818 | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | ubiquitin C | 0.928 |
AZI1 | ACTR1A | ENSP00000393583 | ENSP00000358921 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); Component of a multi-subunit complex involved in microtubule based vesicle motility. It is associated with the centrosome | 0.900 |
AZI1 | BBS4 | ENSP00000393583 | ENSP00000268057 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | Bardet-Biedl syndrome 4; May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane [...] | 0.980 |
AZI1 | CEP290 | ENSP00000393583 | ENSP00000448012 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | centrosomal protein 290kDa; Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Activates ATF4-mediated transcription. Required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells; may play a role in ciliary transport processes | 0.925 |
AZI1 | CEP72 | ENSP00000393583 | ENSP00000264935 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | centrosomal protein 72kDa; Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ/PLK1S1, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs) | 0.956 |
AZI1 | DCTN2 | ENSP00000393583 | ENSP00000408910 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | dynactin 2 (p50); Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development | 0.900 |
AZI1 | OFD1 | ENSP00000393583 | ENSP00000344314 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | oral-facial-digital syndrome 1; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis (By similarity) | 0.913 |
AZI1 | PCM1 | ENSP00000393583 | ENSP00000327077 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | pericentriolar material 1; Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia | 0.982 |
AZI1 | PCNT | ENSP00000393583 | ENSP00000352572 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | pericentrin; Integral component of the filamentous matrix of the centrosome involved in the initial establishment of organized microtubule arrays in both mitosis and meiosis. Plays a role, together with DISC1, in the microtubule network formation. Is an integral component of the pericentriolar material (PCM). May play an important role in preventing premature centrosome splitting during interphase by inhibiting NEK2 kinase activity at the centrosome | 0.915 |
AZI1 | RAB8A | ENSP00000393583 | ENSP00000300935 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | RAB8A, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B and RAB11A participates in epithelial cell polarization | 0.900 |
AZI1 | UBC | ENSP00000393583 | ENSP00000344818 | 5-azacytidine induced 1; May play a role in spermatogenesis (By similarity) | ubiquitin C | 0.963 |