node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AP5Z1 | ATL1 | ENSP00000297562 | ENSP00000351155 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.450 |
AP5Z1 | DDHD1 | ENSP00000297562 | ENSP00000327104 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | 0.655 |
AP5Z1 | ERLIN2 | ENSP00000297562 | ENSP00000276461 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.610 |
AP5Z1 | FA2H | ENSP00000297562 | ENSP00000219368 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.606 |
AP5Z1 | KIF1A | ENSP00000297562 | ENSP00000322791 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | kinesin family member 1A | 0.561 |
AP5Z1 | PNPLA6 | ENSP00000297562 | ENSP00000407509 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy | 0.707 |
AP5Z1 | SPG11 | ENSP00000297562 | ENSP00000261866 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | spastic paraplegia 11 (autosomal recessive) | 0.970 |
AP5Z1 | ZFYVE26 | ENSP00000297562 | ENSP00000251119 | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | zinc finger, FYVE domain containing 26 | 0.970 |
ATL1 | AP5Z1 | ENSP00000351155 | ENSP00000297562 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | 0.450 |
ATL1 | DDHD1 | ENSP00000351155 | ENSP00000327104 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | 0.609 |
ATL1 | SPG11 | ENSP00000351155 | ENSP00000261866 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | spastic paraplegia 11 (autosomal recessive) | 0.540 |
ATL1 | ZFYVE26 | ENSP00000351155 | ENSP00000251119 | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | zinc finger, FYVE domain containing 26 | 0.610 |
DDHD1 | AP5Z1 | ENSP00000327104 | ENSP00000297562 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair | 0.655 |
DDHD1 | ATL1 | ENSP00000327104 | ENSP00000351155 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development | 0.609 |
DDHD1 | ERLIN2 | ENSP00000327104 | ENSP00000276461 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway | 0.685 |
DDHD1 | FA2H | ENSP00000327104 | ENSP00000219368 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids | 0.665 |
DDHD1 | KIF1A | ENSP00000327104 | ENSP00000322791 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | kinesin family member 1A | 0.610 |
DDHD1 | PNPLA6 | ENSP00000327104 | ENSP00000407509 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy | 0.711 |
DDHD1 | SPG11 | ENSP00000327104 | ENSP00000261866 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | spastic paraplegia 11 (autosomal recessive) | 0.609 |
DDHD1 | TBC1D22A | ENSP00000327104 | ENSP00000336724 | DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity | TBC1 domain family, member 22A | 0.761 |