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STRINGSTRING
TBC1D22B TBC1D22B TBC1D22A TBC1D22A ATL1 ATL1 DDHD1 DDHD1 SPG11 SPG11 PNPLA6 PNPLA6 ZFYVE26 ZFYVE26 AP5Z1 AP5Z1 FA2H FA2H KIF1A KIF1A ERLIN2 ERLIN2
"DDHD1" - DDHD domain containing 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
DDHD1DDHD domain containing 1; Phospholipase that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid. The different isoforms may change the substrate specificity (900 aa)    
Predicted Functional Partners:
TBC1D22B
TBC1 domain family, member 22B; May act as a GTPase-activating protein for Rab family protein(s) (By similarity) (505 aa)
            score_image   0.761
TBC1D22A
TBC1 domain family, member 22A (517 aa)
            score_image   0.761
ZFYVE26
zinc finger, FYVE domain containing 26 (2539 aa)
            score_image   0.753
PNPLA6
patatin-like phospholipase domain containing 6; Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy (1375 aa)
      score_image     score_image   0.711
ERLIN2
ER lipid raft associated 2; Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Also involved in ITPR1 degradation by the ERAD pathway (339 aa)
            score_image   0.685
FA2H
fatty acid 2-hydroxylase; Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids (372 aa)
            score_image   0.665
AP5Z1
adaptor-related protein complex 5, zeta 1 subunit; As part of AP-5, a probable fifth adapter protein complex it may be involved in endosomal transport. According to PubMed-20613862 it is a putative helicase required for efficient homologous recombination DNA double-strand break repair (807 aa)
            score_image   0.655
KIF1A
kinesin family member 1A (1690 aa)
            score_image   0.610
ATL1
atlastin GTPase 1; GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. May also regulate Golgi biogenesis. May regulate axonal development (558 aa)
            score_image   0.609
SPG11
spastic paraplegia 11 (autosomal recessive) (2443 aa)
            score_image   0.609
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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