node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP13A2 | EFNA3 | ENSP00000327214 | ENSP00000357393 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity) | 0.736 |
ATP13A2 | EFNA4 | ENSP00000327214 | ENSP00000414378 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils | 0.736 |
ATP13A2 | ENSG00000251246 | ENSP00000327214 | ENSP00000426741 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3 | 0.736 |
ATP13A2 | FBXO7 | ENSP00000327214 | ENSP00000266087 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | 0.739 |
ATP13A2 | GAK | ENSP00000327214 | ENSP00000314499 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.815 |
ATP13A2 | KARS | ENSP00000327214 | ENSP00000325448 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | lysyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), th [...] | 0.811 |
ATP13A2 | LRRK2 | ENSP00000327214 | ENSP00000298910 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes | 0.852 |
ATP13A2 | PARK7 | ENSP00000327214 | ENSP00000340278 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | parkinson protein 7; Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide [...] | 0.847 |
ATP13A2 | PINK1 | ENSP00000327214 | ENSP00000364204 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | 0.837 |
ATP13A2 | UBC | ENSP00000327214 | ENSP00000344818 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | ubiquitin C | 0.890 |
EFNA3 | ATP13A2 | ENSP00000357393 | ENSP00000327214 | ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity) | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.736 |
EFNA3 | GAK | ENSP00000357393 | ENSP00000314499 | ephrin-A3; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity) | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.508 |
EFNA4 | ATP13A2 | ENSP00000414378 | ENSP00000327214 | ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.736 |
EFNA4 | GAK | ENSP00000414378 | ENSP00000314499 | ephrin-A4; Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. May play a role in the interaction between activated B-lymphocytes and dendritic cells in tonsils | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.508 |
ENSG00000251246 | ATP13A2 | ENSP00000426741 | ENSP00000327214 | Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.736 |
ENSG00000251246 | GAK | ENSP00000426741 | ENSP00000314499 | Ephrin-A3; Uncharacterized protein; cDNA FLJ57652, highly similar to Ephrin-A3 | cyclin G associated kinase; Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin- coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 | 0.508 |
FBXO7 | ATP13A2 | ENSP00000266087 | ENSP00000327214 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | ATPase type 13A2; May play a role in intracellular cation homeostasis and the maintenance of neuronal integrity | 0.739 |
FBXO7 | LRRK2 | ENSP00000266087 | ENSP00000298910 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | leucine-rich repeat kinase 2; May play a role in the phosphorylation of proteins central to Parkinson disease. Phosphorylates PRDX3. May also have GTPase activity. Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes | 0.507 |
FBXO7 | PARK7 | ENSP00000266087 | ENSP00000340278 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | parkinson protein 7; Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide [...] | 0.508 |
FBXO7 | PINK1 | ENSP00000266087 | ENSP00000364204 | F-box protein 7; Substrate recognition component of a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5 | PTEN induced putative kinase 1; Protects against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). It is necessary for PARK2 recruitment to dysfunctional mitochondria to initiate their degradation | 0.805 |