node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BGN | BMP4 | ENSP00000327336 | ENSP00000245451 | biglycan; May be involved in collagen fiber assembly (By similarity) | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.701 |
BGN | CNBD2 | ENSP00000327336 | ENSP00000340954 | biglycan; May be involved in collagen fiber assembly (By similarity) | cyclic nucleotide binding domain containing 2 | 0.760 |
BGN | COL1A1 | ENSP00000327336 | ENSP00000225964 | biglycan; May be involved in collagen fiber assembly (By similarity) | collagen, type I, alpha 1 | 0.747 |
BGN | COL1A2 | ENSP00000327336 | ENSP00000297268 | biglycan; May be involved in collagen fiber assembly (By similarity) | collagen, type I, alpha 2 | 0.738 |
BGN | HSP90AA1 | ENSP00000327336 | ENSP00000335153 | biglycan; May be involved in collagen fiber assembly (By similarity) | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
BGN | HSP90AB1 | ENSP00000327336 | ENSP00000325875 | biglycan; May be involved in collagen fiber assembly (By similarity) | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
BGN | PRKAR1A | ENSP00000327336 | ENSP00000351410 | biglycan; May be involved in collagen fiber assembly (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.761 |
BGN | PRKAR1B | ENSP00000327336 | ENSP00000353415 | biglycan; May be involved in collagen fiber assembly (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.764 |
BGN | PRKAR2A | ENSP00000327336 | ENSP00000265563 | biglycan; May be involved in collagen fiber assembly (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.760 |
BGN | PRKAR2B | ENSP00000327336 | ENSP00000265717 | biglycan; May be involved in collagen fiber assembly (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.760 |
BMP4 | BGN | ENSP00000245451 | ENSP00000327336 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | biglycan; May be involved in collagen fiber assembly (By similarity) | 0.701 |
BMP4 | COL1A1 | ENSP00000245451 | ENSP00000225964 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | collagen, type I, alpha 1 | 0.790 |
BMP4 | COL1A2 | ENSP00000245451 | ENSP00000297268 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | collagen, type I, alpha 2 | 0.733 |
CNBD2 | BGN | ENSP00000340954 | ENSP00000327336 | cyclic nucleotide binding domain containing 2 | biglycan; May be involved in collagen fiber assembly (By similarity) | 0.760 |
COL1A1 | BGN | ENSP00000225964 | ENSP00000327336 | collagen, type I, alpha 1 | biglycan; May be involved in collagen fiber assembly (By similarity) | 0.747 |
COL1A1 | BMP4 | ENSP00000225964 | ENSP00000245451 | collagen, type I, alpha 1 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.790 |
COL1A1 | COL1A2 | ENSP00000225964 | ENSP00000297268 | collagen, type I, alpha 1 | collagen, type I, alpha 2 | 0.963 |
COL1A2 | BGN | ENSP00000297268 | ENSP00000327336 | collagen, type I, alpha 2 | biglycan; May be involved in collagen fiber assembly (By similarity) | 0.738 |
COL1A2 | BMP4 | ENSP00000297268 | ENSP00000245451 | collagen, type I, alpha 2 | bone morphogenetic protein 4; Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (By similarity) | 0.733 |
COL1A2 | COL1A1 | ENSP00000297268 | ENSP00000225964 | collagen, type I, alpha 2 | collagen, type I, alpha 1 | 0.963 |