HBG1 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Score

HBG1

hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains (147 aa)

Predicted Functional Partners:

BCL11A

0.767

KLF1

0.762

FYN

0.728

SOX6

0.704

MIPEP

0.683

SLC25A37

0.659

HBA1

0.614

HBA2

0.612

HBS1L

0.610

TFAP4

0.610

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL11A	HBA1	ENSP00000338774	ENSP00000322421	B-cell CLL/lymphoma 11A (zinc finger protein)	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	0.435
BCL11A	HBA2	ENSP00000338774	ENSP00000251595	B-cell CLL/lymphoma 11A (zinc finger protein)	hemoglobin, alpha 2	0.470
BCL11A	HBG1	ENSP00000338774	ENSP00000327431	B-cell CLL/lymphoma 11A (zinc finger protein)	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.767
BCL11A	HBS1L	ENSP00000338774	ENSP00000356811	B-cell CLL/lymphoma 11A (zinc finger protein)	HBS1-like (S. cerevisiae)	0.648
BCL11A	SOX6	ENSP00000338774	ENSP00000324948	B-cell CLL/lymphoma 11A (zinc finger protein)	SRY (sex determining region Y)-box 6; Transcriptional activator. Binds specifically to the DNA sequence 5’-AACAAT-3’. Plays a key role in several developmental processes, including neurogenesis and skeleton formation	0.897
FYN	HBG1	ENSP00000346671	ENSP00000327431	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.728
HBA1	BCL11A	ENSP00000322421	ENSP00000338774	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	B-cell CLL/lymphoma 11A (zinc finger protein)	0.435
HBA1	HBA2	ENSP00000322421	ENSP00000251595	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	hemoglobin, alpha 2	0.900
HBA1	HBG1	ENSP00000322421	ENSP00000327431	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.614
HBA1	KLF1	ENSP00000322421	ENSP00000264834	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...]	0.540
HBA1	SLC25A37	ENSP00000322421	ENSP00000429200	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity)	0.560
HBA2	BCL11A	ENSP00000251595	ENSP00000338774	hemoglobin, alpha 2	B-cell CLL/lymphoma 11A (zinc finger protein)	0.470
HBA2	HBA1	ENSP00000251595	ENSP00000322421	hemoglobin, alpha 2	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	0.900
HBA2	HBG1	ENSP00000251595	ENSP00000327431	hemoglobin, alpha 2	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	0.612
HBA2	KLF1	ENSP00000251595	ENSP00000264834	hemoglobin, alpha 2	Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...]	0.436
HBA2	SLC25A37	ENSP00000251595	ENSP00000429200	hemoglobin, alpha 2	solute carrier family 25 (mitochondrial iron transporter), member 37; Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity)	0.606
HBG1	BCL11A	ENSP00000327431	ENSP00000338774	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	B-cell CLL/lymphoma 11A (zinc finger protein)	0.767
HBG1	FYN	ENSP00000327431	ENSP00000346671	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	FYN oncogene related to SRC, FGR, YES; Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motilit [...]	0.728
HBG1	HBA1	ENSP00000327431	ENSP00000322421	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	hemoglobin, alpha 1; Involved in oxygen transport from the lung to the various peripheral tissues (By similarity)	0.614
HBG1	HBA2	ENSP00000327431	ENSP00000251595	hemoglobin, gamma A; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains	hemoglobin, alpha 2	0.612

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