node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AASDH | ACSM2B | ENSP00000205214 | ENSP00000327453 | aminoadipate-semialdehyde dehydrogenase | acyl-CoA synthetase medium-chain family member 2B; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) | 0.591 |
ACACA | ACACB | ENSP00000344789 | ENSP00000341044 | acetyl-CoA carboxylase alpha | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.999 |
ACACA | ACADS | ENSP00000344789 | ENSP00000242592 | acetyl-CoA carboxylase alpha | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 0.697 |
ACACA | ACLY | ENSP00000344789 | ENSP00000253792 | acetyl-CoA carboxylase alpha | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.983 |
ACACA | ACSM2B | ENSP00000344789 | ENSP00000327453 | acetyl-CoA carboxylase alpha | acyl-CoA synthetase medium-chain family member 2B; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) | 0.916 |
ACACA | ALDH18A1 | ENSP00000344789 | ENSP00000360268 | acetyl-CoA carboxylase alpha | aldehyde dehydrogenase 18 family, member A1 | 0.778 |
ACACA | EHHADH | ENSP00000344789 | ENSP00000231887 | acetyl-CoA carboxylase alpha | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.775 |
ACACA | SREBF1 | ENSP00000344789 | ENSP00000348069 | acetyl-CoA carboxylase alpha | sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’) | 0.968 |
ACACA | SREBF2 | ENSP00000344789 | ENSP00000354476 | acetyl-CoA carboxylase alpha | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.739 |
ACACB | ACACA | ENSP00000341044 | ENSP00000344789 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acetyl-CoA carboxylase alpha | 0.999 |
ACACB | ACADS | ENSP00000341044 | ENSP00000242592 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acyl-CoA dehydrogenase, C-2 to C-3 short chain | 0.696 |
ACACB | ACLY | ENSP00000341044 | ENSP00000253792 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.907 |
ACACB | ACSM2B | ENSP00000341044 | ENSP00000327453 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | acyl-CoA synthetase medium-chain family member 2B; Has medium-chain fatty acid-CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4- unsaturated acids (in vitro) | 0.924 |
ACACB | ALDH18A1 | ENSP00000341044 | ENSP00000360268 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | aldehyde dehydrogenase 18 family, member A1 | 0.778 |
ACACB | EHHADH | ENSP00000341044 | ENSP00000231887 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.780 |
ACACB | SREBF1 | ENSP00000341044 | ENSP00000348069 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | sterol regulatory element binding transcription factor 1; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity). Binds to the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’). Has dual sequence specificity binding to both an E-box motif (5’-ATCACGTGA-3’) and to SRE-1 (5’-ATCACCCCAC-3’) | 0.880 |
ACACB | SREBF2 | ENSP00000341044 | ENSP00000354476 | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | sterol regulatory element binding transcription factor 2; Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the cholesterol and to a lesser degree the fatty acid synthesis pathway (By similarity). Binds the sterol regulatory element 1 (SRE-1) (5’-ATCACCCCAC-3’) found in the flanking region of the LDRL and HMG-CoA synthase genes | 0.652 |
ACADS | ACACA | ENSP00000242592 | ENSP00000344789 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | acetyl-CoA carboxylase alpha | 0.697 |
ACADS | ACACB | ENSP00000242592 | ENSP00000341044 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase | 0.696 |
ACADS | ACLY | ENSP00000242592 | ENSP00000253792 | acyl-CoA dehydrogenase, C-2 to C-3 short chain | ATP citrate lyase; ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine | 0.690 |