node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C22orf32 | CCDC109B | ENSP00000327467 | ENSP00000378145 | chromosome 22 open reading frame 32 | coiled-coil domain containing 109B | 0.959 |
C22orf32 | EFHA1 | ENSP00000327467 | ENSP00000371811 | chromosome 22 open reading frame 32 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.939 |
C22orf32 | IRAK2 | ENSP00000327467 | ENSP00000256458 | chromosome 22 open reading frame 32 | interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization | 0.607 |
C22orf32 | IRAK3 | ENSP00000327467 | ENSP00000261233 | chromosome 22 open reading frame 32 | interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity) | 0.430 |
C22orf32 | IRAK4 | ENSP00000327467 | ENSP00000390651 | chromosome 22 open reading frame 32 | interleukin-1 receptor-associated kinase 4; Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor- signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquit [...] | 0.451 |
C22orf32 | IRF2BP2 | ENSP00000327467 | ENSP00000355568 | chromosome 22 open reading frame 32 | interferon regulatory factor 2 binding protein 2; Acts as a transcriptional corepressor in a IRF2- dependent manner; this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle | 0.430 |
C22orf32 | KRT5 | ENSP00000327467 | ENSP00000252242 | chromosome 22 open reading frame 32 | keratin 5 | 0.810 |
C22orf32 | MCU | ENSP00000327467 | ENSP00000362144 | chromosome 22 open reading frame 32 | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.936 |
C22orf32 | MICU1 | ENSP00000327467 | ENSP00000354415 | chromosome 22 open reading frame 32 | mitochondrial calcium uptake 1 | 0.958 |
C22orf32 | NDUFA6 | ENSP00000327467 | ENSP00000418842 | chromosome 22 open reading frame 32 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone | 0.476 |
CCDC109B | C22orf32 | ENSP00000378145 | ENSP00000327467 | coiled-coil domain containing 109B | chromosome 22 open reading frame 32 | 0.959 |
CCDC109B | EFHA1 | ENSP00000378145 | ENSP00000371811 | coiled-coil domain containing 109B | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | 0.938 |
CCDC109B | MCU | ENSP00000378145 | ENSP00000362144 | coiled-coil domain containing 109B | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.911 |
CCDC109B | MICU1 | ENSP00000378145 | ENSP00000354415 | coiled-coil domain containing 109B | mitochondrial calcium uptake 1 | 0.949 |
EFHA1 | C22orf32 | ENSP00000371811 | ENSP00000327467 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | chromosome 22 open reading frame 32 | 0.939 |
EFHA1 | CCDC109B | ENSP00000371811 | ENSP00000378145 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | coiled-coil domain containing 109B | 0.938 |
EFHA1 | MCU | ENSP00000371811 | ENSP00000362144 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uniporter; Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondrion. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes | 0.973 |
EFHA1 | MICU1 | ENSP00000371811 | ENSP00000354415 | EF-hand domain family, member A1; Involved in mitochondrial uniporter-mediated calcium uptake. Probable regulator of the mitochondrial calcium uniporter (MCU) (By similarity) | mitochondrial calcium uptake 1 | 0.923 |
IRAK2 | C22orf32 | ENSP00000256458 | ENSP00000327467 | interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization | chromosome 22 open reading frame 32 | 0.607 |
IRAK2 | IRAK3 | ENSP00000256458 | ENSP00000261233 | interleukin-1 receptor-associated kinase 2; Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization | interleukin-1 receptor-associated kinase 3; Inhibits dissociation of IRAK1 and IRAK4 from the Toll- like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity) | 0.996 |