node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCC4 | SLC17A1 | ENSP00000366084 | ENSP00000244527 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | 0.568 |
ABCC4 | SLC22A10 | ENSP00000366084 | ENSP00000327569 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 22, member 10 | 0.437 |
ABCC4 | SLC26A6 | ENSP00000366084 | ENSP00000378920 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.691 |
ABCC4 | SLCO1A2 | ENSP00000366084 | ENSP00000305974 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.738 |
ABCC4 | SLCO1C1 | ENSP00000366084 | ENSP00000370964 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) | 0.588 |
ABCC4 | SLCO4C1 | ENSP00000366084 | ENSP00000309741 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | solute carrier organic anion transporter family, member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by e [...] | 0.505 |
ABCC4 | TOP2A | ENSP00000366084 | ENSP00000411532 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | topoisomerase (DNA) II alpha 170kDa | 0.590 |
ABCC4 | TOP2B | ENSP00000366084 | ENSP00000396704 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | topoisomerase (DNA) II beta 180kDa; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. Indirectly involved in vitamin D- coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene | 0.576 |
KLF1 | SLC22A10 | ENSP00000264834 | ENSP00000327569 | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | solute carrier family 22, member 10 | 0.455 |
SLC13A2 | SLC22A10 | ENSP00000392411 | ENSP00000327569 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate | solute carrier family 22, member 10 | 0.484 |
SLC13A2 | SLC26A6 | ENSP00000392411 | ENSP00000378920 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.404 |
SLC17A1 | ABCC4 | ENSP00000244527 | ENSP00000366084 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | 0.568 |
SLC17A1 | SLC22A10 | ENSP00000244527 | ENSP00000327569 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier family 22, member 10 | 0.612 |
SLC17A1 | SLC26A6 | ENSP00000244527 | ENSP00000378920 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier family 26, member 6; Does not seem to be involved in anion transport | 0.580 |
SLC17A1 | SLCO1A2 | ENSP00000244527 | ENSP00000305974 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.523 |
SLC17A1 | SLCO1C1 | ENSP00000244527 | ENSP00000370964 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier organic anion transporter family, member 1C1; Mediates the Na(+)-independent high affinity transport of organic anions such as the thyroid hormones thyroxine (T4) and rT3. Other potential substrates, such as triiodothyronine (T3), 17-beta-glucuronosyl estradiol, estrone-3-sulfate and sulfobromophthalein (BSP) are transported with much lower efficiency. May play a signifiant role in regulating T4 flux into and out of the brain (By similarity) | 0.533 |
SLC17A1 | SLCO4C1 | ENSP00000244527 | ENSP00000309741 | solute carrier family 17 (sodium phosphate), member 1; Important for the resorption of phosphate by the kidney. May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane | solute carrier organic anion transporter family, member 4C1; Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by e [...] | 0.415 |
SLC22A10 | ABCC4 | ENSP00000327569 | ENSP00000366084 | solute carrier family 22, member 10 | ATP-binding cassette, sub-family C (CFTR/MRP), member 4; May be an organic anion pump relevant to cellular detoxification | 0.437 |
SLC22A10 | KLF1 | ENSP00000327569 | ENSP00000264834 | solute carrier family 22, member 10 | Kruppel-like factor 1 (erythroid); Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, a [...] | 0.455 |
SLC22A10 | SLC13A2 | ENSP00000327569 | ENSP00000392411 | solute carrier family 22, member 10 | solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2; Cotransport of sodium ions and dicarboxylates such as succinate and citrate | 0.484 |