GLUD2 protein (Homo sapiens) - STRING network view

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GLUD2

glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission (558 aa)

Predicted Functional Partners:

GLUL

0.960

ALDH18A1

0.952

ALDH4A1

0.927

CPS1

0.926

GAD1

0.917

GAD2

0.917

CS

0.914

GLS

0.911

NIT2

0.910

NAGS

0.907

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALDH18A1	ALDH4A1	ENSP00000360268	ENSP00000290597	aldehyde dehydrogenase 18 family, member A1	aldehyde dehydrogenase 4 family, member A1	0.979
ALDH18A1	CPS1	ENSP00000360268	ENSP00000402608	aldehyde dehydrogenase 18 family, member A1	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	0.766
ALDH18A1	CS	ENSP00000360268	ENSP00000342056	aldehyde dehydrogenase 18 family, member A1	citrate synthase	0.709
ALDH18A1	GLUD2	ENSP00000360268	ENSP00000327589	aldehyde dehydrogenase 18 family, member A1	glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission	0.952
ALDH18A1	GLUL	ENSP00000360268	ENSP00000307900	aldehyde dehydrogenase 18 family, member A1	glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts	0.616
ALDH18A1	NAGS	ENSP00000360268	ENSP00000293404	aldehyde dehydrogenase 18 family, member A1	N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity	0.969
ALDH4A1	ALDH18A1	ENSP00000290597	ENSP00000360268	aldehyde dehydrogenase 4 family, member A1	aldehyde dehydrogenase 18 family, member A1	0.979
ALDH4A1	GAD1	ENSP00000290597	ENSP00000350928	aldehyde dehydrogenase 4 family, member A1	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.927
ALDH4A1	GAD2	ENSP00000290597	ENSP00000259271	aldehyde dehydrogenase 4 family, member A1	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.928
ALDH4A1	GLS	ENSP00000290597	ENSP00000317379	aldehyde dehydrogenase 4 family, member A1	glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity	0.914
ALDH4A1	GLUD2	ENSP00000290597	ENSP00000327589	aldehyde dehydrogenase 4 family, member A1	glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission	0.927
ALDH4A1	GLUL	ENSP00000290597	ENSP00000307900	aldehyde dehydrogenase 4 family, member A1	glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts	0.945
ALDH4A1	NAGS	ENSP00000290597	ENSP00000293404	aldehyde dehydrogenase 4 family, member A1	N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity	0.921
CPS1	ALDH18A1	ENSP00000402608	ENSP00000360268	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	aldehyde dehydrogenase 18 family, member A1	0.766
CPS1	GAD1	ENSP00000402608	ENSP00000350928	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	glutamate decarboxylase 1 (brain, 67kDa); Catalyzes the production of GABA	0.517
CPS1	GAD2	ENSP00000402608	ENSP00000259271	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa); Catalyzes the production of GABA	0.517
CPS1	GLS	ENSP00000402608	ENSP00000317379	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	glutaminase; Catalyzes the first reaction in the primary pathway for the renal catabolism of glutamine. Plays a role in maintaining acid-base homeostasis. Regulates the levels of the neurotransmitter glutamate in the brain. Isoform 2 lacks catalytic activity	0.950
CPS1	GLUD2	ENSP00000402608	ENSP00000327589	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission	0.926
CPS1	GLUL	ENSP00000402608	ENSP00000307900	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	glutamate-ammonia ligase; This enzyme has 2 functions- it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts	0.959
CPS1	NAGS	ENSP00000402608	ENSP00000293404	carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell	N-acetylglutamate synthase; Plays a role in the regulation of ureagenesis by producing variable amounts of N-acetylglutamate (NAG), thus modulating carbamoylphosphate synthase I (CPSI) activity	0.986

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