| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ASNA1 | COG6 | ENSP00000349887 | ENSP00000397441 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.499 |
| ASNA1 | GET4 | ENSP00000349887 | ENSP00000265857 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | 0.999 |
| ASNA1 | UBC | ENSP00000349887 | ENSP00000344818 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | ubiquitin C | 0.863 |
| ASNA1 | WRB | ENSP00000349887 | ENSP00000327716 | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.985 |
| ATP13A1 | UBC | ENSP00000349877 | ENSP00000344818 | ATPase type 13A1 | ubiquitin C | 0.936 |
| ATP13A1 | WRB | ENSP00000349877 | ENSP00000327716 | ATPase type 13A1 | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.706 |
| COG6 | ASNA1 | ENSP00000397441 | ENSP00000349887 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | 0.499 |
| COG6 | GET4 | ENSP00000397441 | ENSP00000265857 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | 0.440 |
| COG6 | WRB | ENSP00000397441 | ENSP00000327716 | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.647 |
| EBPL | WRB | ENSP00000242827 | ENSP00000327716 | emopamil binding protein-like; Does not possess sterol isomerase activity and does not bind sigma ligands | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.614 |
| GET4 | ASNA1 | ENSP00000265857 | ENSP00000349887 | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | arsA arsenite transporter, ATP-binding, homolog 1 (bacterial); ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane pro [...] | 0.999 |
| GET4 | COG6 | ENSP00000265857 | ENSP00000397441 | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | component of oligomeric golgi complex 6; Required for normal Golgi function (By similarity) | 0.440 |
| GET4 | RHCE | ENSP00000265857 | ENSP00000294413 | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | Rh blood group, CcEe antigens | 0.661 |
| GET4 | UBC | ENSP00000265857 | ENSP00000344818 | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | ubiquitin C | 0.871 |
| GET4 | WRB | ENSP00000265857 | ENSP00000327716 | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.659 |
| HMGN1 | UBC | ENSP00000370125 | ENSP00000344818 | high mobility group nucleosome binding domain 1; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity) | ubiquitin C | 0.524 |
| HMGN1 | WRB | ENSP00000370125 | ENSP00000327716 | high mobility group nucleosome binding domain 1; Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in an unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity) | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.860 |
| RHAG | WRB | ENSP00000360217 | ENSP00000327716 | Rh-associated glycoprotein; Associated with rhesus blood group antigen expression. May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.603 |
| RHCE | GET4 | ENSP00000294413 | ENSP00000265857 | Rh blood group, CcEe antigens | golgi to ER traffic protein 4 homolog (S. cerevisiae); Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40- it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting | 0.661 |
| RHCE | WRB | ENSP00000294413 | ENSP00000327716 | Rh blood group, CcEe antigens | tryptophan rich basic protein; Receptor for ASNA1/TRC40-mediated insertion of tail- anchored (TA) proteins into the ER membrane | 0.686 |
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