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STRINGSTRING
SPAG9 SPAG9 CD9 CD9 IZUMO1 IZUMO1 GPR15 GPR15 POU2AF1 POU2AF1 FAM71D FAM71D
"IZUMO1" - izumo sperm-egg fusion 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IZUMO1izumo sperm-egg fusion 1; Involved in the fertilization process. May be involved in the fusion of the sperm with the egg (350 aa)    
Predicted Functional Partners:
CD9
CD9 molecule; Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion (228 aa)
          score_image score_image   0.912
SPAG9
sperm associated antigen 9 (1321 aa)
            score_image   0.759
GPR15
G protein-coupled receptor 15; Probable chemokine receptor. Alternative coreceptor with CD4 for HIV-1 infection (360 aa)
            score_image   0.705
POU2AF1
POU class 2 associating factor 1; Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (256 aa)
            score_image   0.581
FAM71D
family with sequence similarity 71, member D (422 aa)
            score_image   0.499
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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