| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IFNA2 | IL10 | ENSP00000369554 | ENSP00000412237 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | 0.876 |
| IFNA2 | IL10RB | ENSP00000369554 | ENSP00000290200 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.607 |
| IFNA2 | IL28A | ENSP00000369554 | ENSP00000333639 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.754 |
| IFNA2 | IL28B | ENSP00000369554 | ENSP00000409000 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.753 |
| IFNA2 | IL28RA | ENSP00000369554 | ENSP00000327824 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium | 0.948 |
| IFNA2 | IL29 | ENSP00000369554 | ENSP00000329991 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.662 |
| IFNA2 | JAK1 | ENSP00000369554 | ENSP00000343204 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.943 |
| IFNA2 | TYK2 | ENSP00000369554 | ENSP00000264818 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.937 |
| IFNE | IL28A | ENSP00000418018 | ENSP00000333639 | interferon, epsilon | interleukin 28A (interferon, lambda 2); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.554 |
| IFNE | IL28B | ENSP00000418018 | ENSP00000409000 | interferon, epsilon | interleukin 28B (interferon, lambda 3); Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the [...] | 0.551 |
| IFNE | IL28RA | ENSP00000418018 | ENSP00000327824 | interferon, epsilon | interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium | 0.864 |
| IFNE | IL29 | ENSP00000418018 | ENSP00000329991 | interferon, epsilon | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.521 |
| IL10 | IFNA2 | ENSP00000412237 | ENSP00000369554 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | 0.876 |
| IL10 | IL10RB | ENSP00000412237 | ENSP00000290200 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | 0.991 |
| IL10 | IL19 | ENSP00000412237 | ENSP00000343000 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 19; May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity) | 0.899 |
| IL10 | IL28RA | ENSP00000412237 | ENSP00000327824 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 28 receptor, alpha (interferon, lambda receptor); The IFNLR1/IL10RB dimer is a receptor for IFNL1, IFNL2 and IFNL3. The ligand/receptor complex seems to signal through the Jak-STAT pathway. Seems not to be essential for early virus- activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium | 0.851 |
| IL10 | IL29 | ENSP00000412237 | ENSP00000329991 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | interleukin 29 (interferon, lambda 1); Cytokine with immunomodulatory activity. May play a role in antiviral immunity. Up-regulates MHC class I antigen expression. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1. The ligand/receptor complex seems to signal through the Jak-STAT pathway | 0.416 |
| IL10 | JAK1 | ENSP00000412237 | ENSP00000343204 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | Janus kinase 1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor | 0.952 |
| IL10 | TYK2 | ENSP00000412237 | ENSP00000264818 | interleukin 10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells | tyrosine kinase 2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain | 0.513 |
| IL10RB | IFNA2 | ENSP00000290200 | ENSP00000369554 | interleukin 10 receptor, beta; Shared cell surface receptor required for the activation of five class 2 cytokines- IL10, IL22, IL26, IL28, and IFNL1 | interferon, alpha 2; Produced by macrophages, IFN-alpha have antiviral activities | 0.607 |
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