SRPR protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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SRPR

signal recognition particle receptor (docking protein); Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (638 aa)

Predicted Functional Partners:

SRPRB

0.997

SRP54

0.993

RPL23A

0.977

SSR2

0.960

RPS8

0.951

RPS19

0.947

SRP68

0.946

SEC11A

0.945

SEC11C

0.945

RPLP0

0.944

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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... protein annotations:

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a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RPL23A	RPLP0	ENSP00000389103	ENSP00000339027	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	0.999
RPL23A	RPS19	ENSP00000389103	ENSP00000470004	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits	0.998
RPL23A	RPS8	ENSP00000389103	ENSP00000379888	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	ribosomal protein S8	0.999
RPL23A	SEC11A	ENSP00000389103	ENSP00000268220	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
RPL23A	SEC11C	ENSP00000389103	ENSP00000468633	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
RPL23A	SRP54	ENSP00000389103	ENSP00000216774	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	signal recognition particle 54kDa; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)	0.999
RPL23A	SRP68	ENSP00000389103	ENSP00000312066	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	signal recognition particle 68kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.932
RPL23A	SRPR	ENSP00000389103	ENSP00000328023	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	signal recognition particle receptor (docking protein); Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system	0.977
RPL23A	SRPRB	ENSP00000389103	ENSP00000418401	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	0.900
RPL23A	SSR2	ENSP00000389103	ENSP00000295702	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins	0.903
RPLP0	RPL23A	ENSP00000339027	ENSP00000389103	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	ribosomal protein L23a; This protein binds to a specific region on the 26S rRNA (By similarity)	0.999
RPLP0	RPS19	ENSP00000339027	ENSP00000470004	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	ribosomal protein S19; Required for pre-rRNA processing and maturation of 40S ribosomal subunits	0.996
RPLP0	RPS8	ENSP00000339027	ENSP00000379888	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	ribosomal protein S8	0.999
RPLP0	SEC11A	ENSP00000339027	ENSP00000268220	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	SEC11 homolog A (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
RPLP0	SEC11C	ENSP00000339027	ENSP00000468633	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	SEC11 homolog C (S. cerevisiae); Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity)	0.900
RPLP0	SRP54	ENSP00000339027	ENSP00000216774	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	signal recognition particle 54kDa; Binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein)	0.941
RPLP0	SRP68	ENSP00000339027	ENSP00000312066	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	signal recognition particle 68kDa; Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function	0.900
RPLP0	SRPR	ENSP00000339027	ENSP00000328023	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	signal recognition particle receptor (docking protein); Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system	0.944
RPLP0	SRPRB	ENSP00000339027	ENSP00000418401	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	signal recognition particle receptor, B subunit; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR (By similarity)	0.907
RPLP0	SSR2	ENSP00000339027	ENSP00000295702	ribosomal protein, large, P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10 (By similarity)	signal sequence receptor, beta (translocon-associated protein beta); TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins	0.903

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