| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IGDCC3 | MCF2L2 | ENSP00000332773 | ENSP00000328118 | immunoglobulin superfamily, DCC subclass, member 3 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.575 |
| IGDCC4 | MCF2L2 | ENSP00000319623 | ENSP00000328118 | immunoglobulin superfamily, DCC subclass, member 4 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.515 |
| LRRC16A | MCF2L2 | ENSP00000331983 | ENSP00000328118 | leucine rich repeat containing 16A; Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity) | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.654 |
| MCF2L2 | IGDCC3 | ENSP00000328118 | ENSP00000332773 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | immunoglobulin superfamily, DCC subclass, member 3 | 0.575 |
| MCF2L2 | IGDCC4 | ENSP00000328118 | ENSP00000319623 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | immunoglobulin superfamily, DCC subclass, member 4 | 0.515 |
| MCF2L2 | LRRC16A | ENSP00000328118 | ENSP00000331983 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | leucine rich repeat containing 16A; Binds CAPZA2 with high affinity and significantly decreases CAPZA2 affinity for actin barbed ends. Increases the rate of elongation from seeds in the presence of CAPZA2, however, seems unable to nucleate filaments. Rapidly uncaps barbed ends capped by CAPZA2 and enhances barbed-end actin polymerization (By similarity) | 0.654 |
| MCF2L2 | NOTCH1 | ENSP00000328118 | ENSP00000277541 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.534 |
| MCF2L2 | NOTCH2 | ENSP00000328118 | ENSP00000256646 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | notch 2 | 0.534 |
| MCF2L2 | NOTCH3 | ENSP00000328118 | ENSP00000263388 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.534 |
| MCF2L2 | NOTCH4 | ENSP00000328118 | ENSP00000364163 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | notch 4 | 0.534 |
| MCF2L2 | RAC1 | ENSP00000328118 | ENSP00000348461 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.874 |
| MCF2L2 | RLTPR | ENSP00000328118 | ENSP00000334958 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | RGD motif, leucine rich repeats, tropomodulin domain and proline-rich containing | 0.654 |
| MCF2L2 | TXNDC11 | ENSP00000328118 | ENSP00000283033 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | thioredoxin domain containing 11; May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation | 0.522 |
| NOTCH1 | MCF2L2 | ENSP00000277541 | ENSP00000328118 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.534 |
| NOTCH1 | NOTCH3 | ENSP00000277541 | ENSP00000263388 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | 0.961 |
| NOTCH1 | NOTCH4 | ENSP00000277541 | ENSP00000364163 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | notch 4 | 0.913 |
| NOTCH1 | RAC1 | ENSP00000277541 | ENSP00000348461 | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.487 |
| NOTCH2 | MCF2L2 | ENSP00000256646 | ENSP00000328118 | notch 2 | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.534 |
| NOTCH3 | MCF2L2 | ENSP00000263388 | ENSP00000328118 | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | MCF.2 cell line derived transforming sequence-like 2; Probably functions as a guanine nucleotide exchange factor (By similarity) | 0.534 |
| NOTCH3 | NOTCH1 | ENSP00000263388 | ENSP00000277541 | notch 3; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) | notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...] | 0.961 |
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