Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CLN8 | ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation); Could play a role in cell proliferation during neuronal differentiation and in protection against cell death (286 aa) | ||||||||||||
Predicted Functional Partners:
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 | ENSG00000261832 | Battenin; CLN3 protein; Uncharacterized protein (360 aa) |
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0.905 | ||||||||||
 | CLN6 | ceroid-lipofuscinosis, neuronal 6, late infantile, variant (311 aa) |
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0.901 | ||||||||||
 | CLN3 | ceroid-lipofuscinosis, neuronal 3 (438 aa) |
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0.900 | ||||||||||
 | CLN5 | ceroid-lipofuscinosis, neuronal 5 (407 aa) |
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0.891 | ||||||||||
 | TPP1 | tripeptidyl peptidase I; Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus (By similarity) (563 aa) |
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0.832 | ||||||||||
 | MFSD8 | major facilitator superfamily domain containing 8; May be a carrier that transport small solutes by using chemiosmotic ion gradients (Potential) (518 aa) |
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0.821 | ||||||||||
 | PPT1 | palmitoyl-protein thioesterase 1; Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (306 aa) |
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0.770 | ||||||||||
 | CERS1 | ceramide synthase 1; May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked stearoyl- (C18) ceramide) in a fumonisin B1-independent manner (By similarity) (350 aa) |
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0.680 | ||||||||||
 | DLGAP2 | discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (975 aa) |
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0.661 | ||||||||||
 | TLCD2 | TLC domain containing 2 (264 aa) |
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0.608 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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