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GNAO1 GNAO1 GNAI1 GNAI1 GNA12 GNA12 CXCR3 CXCR3 S1PR4 S1PR4 CNR1 CNR1 S1PR5 S1PR5 CXCL12 CXCL12 LPAR5 LPAR5 LPAR3 LPAR3 CXCL13 CXCL13
"S1PR5" - sphingosine-1-phosphate receptor 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
S1PR5sphingosine-1-phosphate receptor 5; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. Is coupled to both the G(i/0)alpha and G(12) subclass of heteromeric G-proteins (By similarity). May play a regulatory role in the transformation of radial glial cells into astrocytes and may affect proliferative activity of these cells (398 aa)    
Predicted Functional Partners:
GNAI1
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (354 aa)
        score_image score_image     0.954
GNA12
guanine nucleotide binding protein (G protein) alpha 12; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (381 aa)
        score_image score_image     0.954
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14 (354 aa)
        score_image score_image     0.954
LPAR5
lysophosphatidic acid receptor 5; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities (372 aa)
          score_image score_image   0.925
CXCL13
chemokine (C-X-C motif) ligand 13; Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B- lymphocytes. Binds to BLR1/CXCR5 (109 aa)
          score_image score_image   0.920
CNR1
cannabinoid receptor 1 (brain) (472 aa)
          score_image score_image score_image 0.913
S1PR4
sphingosine-1-phosphate receptor 4; Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes (384 aa)
          score_image score_image score_image 0.913
CXCR3
chemokine (C-X-C motif) receptor 3; Receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HMC) (415 aa)
          score_image score_image   0.911
CXCL12
chemokine (C-X-C motif) ligand 12 (140 aa)
          score_image score_image   0.910
LPAR3
lysophosphatidic acid receptor 3; Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (353 aa)
          score_image score_image score_image 0.910
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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