| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | DENND5A | ENSP00000363822 | ENSP00000328524 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 0.573 |
| AR | MED12L | ENSP00000363822 | ENSP00000417235 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | mediator complex subunit 12-like; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) | 0.573 |
| AR | ZBTB1 | ENSP00000363822 | ENSP00000378201 | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | zinc finger and BTB domain containing 1; May be involved in transcriptional regulation | 0.587 |
| AVL9 | DENND5A | ENSP00000315568 | ENSP00000328524 | AVL9 homolog (S. cerevisiase); Functions in cell migration | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 0.545 |
| AVL9 | NUPL1 | ENSP00000315568 | ENSP00000371155 | AVL9 homolog (S. cerevisiase); Functions in cell migration | nucleoporin like 1; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity) | 0.698 |
| DENND5A | AR | ENSP00000328524 | ENSP00000363822 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.573 |
| DENND5A | AVL9 | ENSP00000328524 | ENSP00000315568 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | AVL9 homolog (S. cerevisiase); Functions in cell migration | 0.545 |
| DENND5A | DONSON | ENSP00000328524 | ENSP00000307143 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | 0.491 |
| DENND5A | GGNBP2 | ENSP00000328524 | ENSP00000307617 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | gametogenetin binding protein 2; May be involved in spermatogenesis | 0.518 |
| DENND5A | MED12L | ENSP00000328524 | ENSP00000417235 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | mediator complex subunit 12-like; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) | 0.496 |
| DENND5A | MRVI1 | ENSP00000328524 | ENSP00000412130 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | murine retrovirus integration site 1 homolog; Plays a role as NO/PRKG1-dependent regulator of IP3- induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation | 0.615 |
| DENND5A | NUPL1 | ENSP00000328524 | ENSP00000371155 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | nucleoporin like 1; Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane (By similarity) | 0.536 |
| DENND5A | WDR33 | ENSP00000328524 | ENSP00000325377 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | WD repeat domain 33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends | 0.494 |
| DENND5A | XRN2 | ENSP00000328524 | ENSP00000366396 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription | 0.644 |
| DENND5A | ZBTB1 | ENSP00000328524 | ENSP00000378201 | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | zinc finger and BTB domain containing 1; May be involved in transcriptional regulation | 0.514 |
| DONSON | DENND5A | ENSP00000307143 | ENSP00000328524 | downstream neighbor of SON; Essential for DNA amplification in the ovary and required for cell proliferation during development (By similarity) | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 0.491 |
| GGNBP2 | DENND5A | ENSP00000307617 | ENSP00000328524 | gametogenetin binding protein 2; May be involved in spermatogenesis | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 0.518 |
| GGNBP2 | WDR33 | ENSP00000307617 | ENSP00000325377 | gametogenetin binding protein 2; May be involved in spermatogenesis | WD repeat domain 33; Essential for both cleavage and polyadenylation of pre- mRNA 3’ ends | 0.485 |
| MED12L | AR | ENSP00000417235 | ENSP00000363822 | mediator complex subunit 12-like; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) | androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3 | 0.573 |
| MED12L | DENND5A | ENSP00000417235 | ENSP00000328524 | mediator complex subunit 12-like; May be a component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity) | DENN/MADD domain containing 5A; Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form | 0.496 |
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