| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTRT3 | WBP2NL | ENSP00000333037 | ENSP00000328800 | actin-related protein T3 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.603 |
| C22orf29 | FAM83F | ENSP00000330596 | ENSP00000330432 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | family with sequence similarity 83, member F | 0.724 |
| C22orf29 | LOC284912 | ENSP00000330596 | ENSP00000471799 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | Hypothetical gene supported by BC001801 | 0.726 |
| C22orf29 | WBP2NL | ENSP00000330596 | ENSP00000328800 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.507 |
| FAM83F | C22orf29 | ENSP00000330432 | ENSP00000330596 | family with sequence similarity 83, member F | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.724 |
| FAM83F | LOC284912 | ENSP00000330432 | ENSP00000471799 | family with sequence similarity 83, member F | Hypothetical gene supported by BC001801 | 0.703 |
| FAM83F | WBP2NL | ENSP00000330432 | ENSP00000328800 | family with sequence similarity 83, member F | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.499 |
| LOC284912 | C22orf29 | ENSP00000471799 | ENSP00000330596 | Hypothetical gene supported by BC001801 | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.726 |
| LOC284912 | FAM83F | ENSP00000471799 | ENSP00000330432 | Hypothetical gene supported by BC001801 | family with sequence similarity 83, member F | 0.703 |
| LOC284912 | WBP2NL | ENSP00000471799 | ENSP00000328800 | Hypothetical gene supported by BC001801 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.476 |
| MAGI3 | WBP2NL | ENSP00000304604 | ENSP00000328800 | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.419 |
| PLCZ1 | WBP2NL | ENSP00000266505 | ENSP00000328800 | phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...] | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.613 |
| UCHL3 | WBP2NL | ENSP00000366819 | ENSP00000328800 | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | 0.535 |
| WBP2NL | ACTRT3 | ENSP00000328800 | ENSP00000333037 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | actin-related protein T3 | 0.603 |
| WBP2NL | C22orf29 | ENSP00000328800 | ENSP00000330596 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | chromosome 22 open reading frame 29; Could induce apoptosis in a BH3 domain-dependent manner. The direct interaction network of Bcl-2 family members may play a key role in modulation BOP intrinsic apoptotic signaling activity | 0.507 |
| WBP2NL | FAM83F | ENSP00000328800 | ENSP00000330432 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | family with sequence similarity 83, member F | 0.499 |
| WBP2NL | LOC284912 | ENSP00000328800 | ENSP00000471799 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | Hypothetical gene supported by BC001801 | 0.476 |
| WBP2NL | MAGI3 | ENSP00000328800 | ENSP00000304604 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | membrane associated guanylate kinase, WW and PDZ domain containing 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK sig [...] | 0.419 |
| WBP2NL | PLCZ1 | ENSP00000328800 | ENSP00000266505 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | phospholipase C, zeta 1; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)- dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg- activating soluble sperm factor that is transferred from the sperm into the egg [...] | 0.613 |
| WBP2NL | UCHL3 | ENSP00000328800 | ENSP00000366819 | WBP2 N-terminal like; May play a role in meotic resumption and pronuclear formation, mediated by a WW domain-signaling pathway during fertilization (By similarity) | ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase); Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3", and exhibits a preference towards ’Lys-48’-linked Ubiquitin chains. Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGF [...] | 0.535 |
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