node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANK3 | SCN2B | ENSP00000280772 | ENSP00000278947 | ankyrin 3, node of Ranvier (ankyrin G); In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments | sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity) | 0.405 |
ANK3 | SCN4B | ENSP00000280772 | ENSP00000322460 | ankyrin 3, node of Ranvier (ankyrin G); In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments | sodium channel, voltage-gated, type IV, beta subunit; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity) | 0.431 |
ANK3 | SCN5A | ENSP00000280772 | ENSP00000328968 | ankyrin 3, node of Ranvier (ankyrin G); In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments | sodium channel, voltage-gated, type V, alpha subunit | 0.965 |
ANK3 | UBC | ENSP00000280772 | ENSP00000344818 | ankyrin 3, node of Ranvier (ankyrin G); In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments | ubiquitin C | 0.674 |
CALM1 | CALM2 | ENSP00000349467 | ENSP00000272298 | calmodulin 1 (phosphorylase kinase, delta) | calmodulin 2 (phosphorylase kinase, delta) | 0.901 |
CALM1 | SCN5A | ENSP00000349467 | ENSP00000328968 | calmodulin 1 (phosphorylase kinase, delta) | sodium channel, voltage-gated, type V, alpha subunit | 0.935 |
CALM1 | UBC | ENSP00000349467 | ENSP00000344818 | calmodulin 1 (phosphorylase kinase, delta) | ubiquitin C | 0.932 |
CALM2 | CALM1 | ENSP00000272298 | ENSP00000349467 | calmodulin 2 (phosphorylase kinase, delta) | calmodulin 1 (phosphorylase kinase, delta) | 0.901 |
CALM2 | FGF12 | ENSP00000272298 | ENSP00000413496 | calmodulin 2 (phosphorylase kinase, delta) | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.902 |
CALM2 | FGF13 | ENSP00000272298 | ENSP00000359635 | calmodulin 2 (phosphorylase kinase, delta) | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | 0.903 |
CALM2 | SCN5A | ENSP00000272298 | ENSP00000328968 | calmodulin 2 (phosphorylase kinase, delta) | sodium channel, voltage-gated, type V, alpha subunit | 0.985 |
CALM2 | UBC | ENSP00000272298 | ENSP00000344818 | calmodulin 2 (phosphorylase kinase, delta) | ubiquitin C | 0.978 |
FGF12 | CALM2 | ENSP00000413496 | ENSP00000272298 | fibroblast growth factor 12; Probably involved in nervous system development and function | calmodulin 2 (phosphorylase kinase, delta) | 0.902 |
FGF12 | SCN5A | ENSP00000413496 | ENSP00000328968 | fibroblast growth factor 12; Probably involved in nervous system development and function | sodium channel, voltage-gated, type V, alpha subunit | 0.965 |
FGF13 | CALM2 | ENSP00000359635 | ENSP00000272298 | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | calmodulin 2 (phosphorylase kinase, delta) | 0.903 |
FGF13 | SCN5A | ENSP00000359635 | ENSP00000328968 | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | sodium channel, voltage-gated, type V, alpha subunit | 0.991 |
KCNH2 | SCN2B | ENSP00000262186 | ENSP00000278947 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | sodium channel, voltage-gated, type II, beta subunit; Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier (By similarity) | 0.422 |
KCNH2 | SCN3B | ENSP00000262186 | ENSP00000299333 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | sodium channel, voltage-gated, type III, beta subunit; Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity) | 0.424 |
KCNH2 | SCN4B | ENSP00000262186 | ENSP00000322460 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | sodium channel, voltage-gated, type IV, beta subunit; Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation (By similarity) | 0.582 |
KCNH2 | SCN5A | ENSP00000262186 | ENSP00000328968 | potassium voltage-gated channel, subfamily H (eag-related), member 2; Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1 | sodium channel, voltage-gated, type V, alpha subunit | 0.920 |