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SYT14 SYT14 RAB27A RAB27A RAB27B RAB27B RPH3AL RPH3AL RAB3C RAB3C RIMS2 RIMS2 UNC13B UNC13B RAB3B RAB3B SNAP25 SNAP25 RAB3D RAB3D RAB3A RAB3A
"RPH3AL" - rabphilin 3A-like (without C2 domains) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
RPH3ALrabphilin 3A-like (without C2 domains); Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells (By similarity). Acts as a potential RAB3B effector protein in epithelial cells (315 aa)    
Predicted Functional Partners:
RAB27A
RAB27A, member RAS oncogene family; Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse (221 aa)
        score_image   score_image   0.933
RAB27B
RAB27B, member RAS oncogene family; May be involved in targeting uroplakins to urothelial apical membranes (By similarity) (218 aa)
        score_image   score_image   0.882
RAB3C
RAB3C, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (227 aa)
        score_image   score_image   0.879
RAB3A
RAB3A, member RAS oncogene family; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (220 aa)
        score_image   score_image   0.867
RAB3B
RAB3B, member RAS oncogene family; Protein transport. Probably involved in vesicular traffic (By similarity) (219 aa)
        score_image   score_image   0.835
RAB3D
RAB3D, member RAS oncogene family; Protein transport. Probably involved in regulated exocytosis (By similarity) (219 aa)
        score_image   score_image   0.835
SNAP25
synaptosomal-associated protein, 25kDa (206 aa)
            score_image   0.779
SYT14
synaptotagmin XIV (619 aa)
            score_image   0.636
RIMS2
regulating synaptic membrane exocytosis 2; Rab effector involved in exocytosis. May act as scaffold protein (1349 aa)
        score_image   score_image score_image 0.633
UNC13B
unc-13 homolog B (C. elegans); Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity) (1591 aa)
        score_image   score_image   0.617
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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