Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SETD4 | SET domain containing 4 (440 aa) | ||||||||||||
Predicted Functional Partners:
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 | SETD5 | SET domain containing 5 (1442 aa) |
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0.816 | ||||||||||
 | SETD6 | SET domain containing 6; Protein-lysine N-methyltransferase that specifically monomethylates ’Lys-310’ of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity (473 aa) |
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0.774 | |||||||||
 | MRPL39 | mitochondrial ribosomal protein L39 (353 aa) |
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0.612 | |||||||||
 | PRDM15 | PR domain containing 15; May be involved in transcriptional regulation (1507 aa) |
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0.588 | ||||||||||
 | C2CD2 | C2 calcium-dependent domain containing 2 (696 aa) |
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0.587 | ||||||||||
 | DNAJC28 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone (388 aa) |
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0.584 | ||||||||||
 | ENSG00000161939 | RNASEK-C17orf49 readthrough (non-protein coding) (233 aa) |
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0.560 | ||||||||||
 | SETDB2 | SET domain, bifurcated 2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates ’Lys-9’ of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis (719 aa) |
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0.541 | ||||||||||
 | YBEY | ybeY metallopeptidase (putative) (167 aa) |
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0.537 | ||||||||||
 | FAM3B | family with sequence similarity 3, member B; Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner (235 aa) |
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0.536 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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