| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| LSS | NLN | ENSP00000348762 | ENSP00000370372 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | 0.472 |
| LSS | SNN | ENSP00000348762 | ENSP00000329287 | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | stannin; Plays a role in the toxic effects of organotins | 0.437 |
| NLN | LSS | ENSP00000370372 | ENSP00000348762 | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.472 |
| NLN | SNN | ENSP00000370372 | ENSP00000329287 | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | stannin; Plays a role in the toxic effects of organotins | 0.544 |
| NLN | SPN | ENSP00000370372 | ENSP00000353238 | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...] | 0.418 |
| PTK6 | SNN | ENSP00000217185 | ENSP00000329287 | PTK6 protein tyrosine kinase 6; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins- KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors- STAT3 and STAT5A/B and a variety of signaling mol [...] | stannin; Plays a role in the toxic effects of organotins | 0.520 |
| SNN | LSS | ENSP00000329287 | ENSP00000348762 | stannin; Plays a role in the toxic effects of organotins | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase); Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus | 0.437 |
| SNN | NLN | ENSP00000329287 | ENSP00000370372 | stannin; Plays a role in the toxic effects of organotins | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | 0.544 |
| SNN | PTK6 | ENSP00000329287 | ENSP00000217185 | stannin; Plays a role in the toxic effects of organotins | PTK6 protein tyrosine kinase 6; Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia, as well as tumor growth. Function seems to be context dependent and differ depending on cell type, as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins- KHDRBS1/SAM68, KHDRBS2/SLM1, KHDRBS3/SLM2 and SFPQ/PSF; transcription factors- STAT3 and STAT5A/B and a variety of signaling mol [...] | 0.520 |
| SNN | SPN | ENSP00000329287 | ENSP00000353238 | stannin; Plays a role in the toxic effects of organotins | sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...] | 0.516 |
| SNN | YWHAZ | ENSP00000329287 | ENSP00000309503 | stannin; Plays a role in the toxic effects of organotins | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | 0.824 |
| SPN | NLN | ENSP00000353238 | ENSP00000370372 | sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...] | neurolysin (metallopeptidase M3 family); Hydrolyzes oligopeptides such as neurotensin, bradykinin and dynorphin A (By similarity) | 0.418 |
| SPN | SNN | ENSP00000353238 | ENSP00000329287 | sialophorin; One of the major glycoproteins of thymocytes and T lymphocytes. Plays a role in the physicochemical properties of the T-cell surface and in lectin binding. Presents carbohydrate ligands to selectins. Has an extended rodlike structure that could protrude above the glycocalyx of the cell and allow multiple glycan chains to be accessible for binding. Is a counter-receptor for SN/Siglec-1 (By similarity). During T-cell activation is actively removed from the T-cell-APC (antigen-presenting cell) contact site thus suggesting a negative regulatory role in adaptive immune response [...] | stannin; Plays a role in the toxic effects of organotins | 0.516 |
| YWHAZ | SNN | ENSP00000309503 | ENSP00000329287 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | stannin; Plays a role in the toxic effects of organotins | 0.824 |
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