node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS7A | FAM188A | ENSP00000229251 | ENSP00000277632 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | family with sequence similarity 188, member A | 0.455 |
COPS7A | GHITM | ENSP00000229251 | ENSP00000361207 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | 0.586 |
COPS7A | GKN2 | ENSP00000229251 | ENSP00000329292 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | gastrokine 2 | 0.480 |
FAM188A | COPS7A | ENSP00000277632 | ENSP00000229251 | family with sequence similarity 188, member A | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | 0.455 |
FAM188A | GHITM | ENSP00000277632 | ENSP00000361207 | family with sequence similarity 188, member A | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | 0.795 |
FAM188A | GKN2 | ENSP00000277632 | ENSP00000329292 | family with sequence similarity 188, member A | gastrokine 2 | 0.581 |
FAM20C | GKN2 | ENSP00000322323 | ENSP00000329292 | family with sequence similarity 20, member C; Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif | gastrokine 2 | 0.497 |
GHITM | COPS7A | ENSP00000361207 | ENSP00000229251 | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | 0.586 |
GHITM | FAM188A | ENSP00000361207 | ENSP00000277632 | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | family with sequence similarity 188, member A | 0.795 |
GHITM | GKN2 | ENSP00000361207 | ENSP00000329292 | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | gastrokine 2 | 0.505 |
GKN2 | COPS7A | ENSP00000329292 | ENSP00000229251 | gastrokine 2 | COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis); Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association w [...] | 0.480 |
GKN2 | FAM188A | ENSP00000329292 | ENSP00000277632 | gastrokine 2 | family with sequence similarity 188, member A | 0.581 |
GKN2 | FAM20C | ENSP00000329292 | ENSP00000322323 | gastrokine 2 | family with sequence similarity 20, member C; Calcium-binding kinase that phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the secretory calcium binding phosphoproteins (SCPP). Preferencially phosphorylates its targets within the S-x-E/pS motif | 0.497 |
GKN2 | GHITM | ENSP00000329292 | ENSP00000361207 | gastrokine 2 | growth hormone inducible transmembrane protein; Required for the mitochondrial tubular network and cristae organization. Involved in apoptotic release of cytochrome c | 0.505 |
GKN2 | SGOL1 | ENSP00000329292 | ENSP00000263753 | gastrokine 2 | shugoshin-like 1 (S. pombe) | 0.407 |
GKN2 | TFF1 | ENSP00000329292 | ENSP00000291527 | gastrokine 2 | trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine | 0.955 |
GKN2 | TFF2 | ENSP00000329292 | ENSP00000291526 | gastrokine 2 | trefoil factor 2; Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity) | 0.908 |
GKN2 | TMEM189 | ENSP00000329292 | ENSP00000450635 | gastrokine 2 | transmembrane protein 189 | 0.407 |
SGOL1 | GKN2 | ENSP00000263753 | ENSP00000329292 | shugoshin-like 1 (S. pombe) | gastrokine 2 | 0.407 |
TFF1 | GKN2 | ENSP00000291527 | ENSP00000329292 | trefoil factor 1; Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine | gastrokine 2 | 0.955 |