| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GABRA3 | GLRA2 | ENSP00000359334 | ENSP00000218075 | gamma-aminobutyric acid (GABA) A receptor, alpha 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | glycine receptor, alpha 2; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | 0.574 |
| GABRA3 | NXPH3 | ENSP00000359334 | ENSP00000329295 | gamma-aminobutyric acid (GABA) A receptor, alpha 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.517 |
| GLRA2 | GABRA3 | ENSP00000218075 | ENSP00000359334 | glycine receptor, alpha 2; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | gamma-aminobutyric acid (GABA) A receptor, alpha 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | 0.574 |
| GLRA2 | NXPH3 | ENSP00000218075 | ENSP00000329295 | glycine receptor, alpha 2; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.621 |
| KRT27 | NXPH3 | ENSP00000301656 | ENSP00000329295 | keratin 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity) | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.503 |
| LCAT | NXPH3 | ENSP00000264005 | ENSP00000329295 | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.503 |
| NCDN | NXPH3 | ENSP00000348394 | ENSP00000329295 | neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.649 |
| NCDN | PLIN2 | ENSP00000348394 | ENSP00000276914 | neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth | perilipin 2; May be involved in development and maintenance of adipose tissue (By similarity) | 0.401 |
| NCDN | TINAGL1 | ENSP00000348394 | ENSP00000271064 | neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth | tubulointerstitial nephritis antigen-like 1; May be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells. This is a non catalytic peptidase C1 family protein (By similarity) | 0.413 |
| NPS | NXPH3 | ENSP00000381105 | ENSP00000329295 | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.749 |
| NRXN1 | NXPH3 | ENSP00000385142 | ENSP00000329295 | neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | 0.736 |
| NXPH3 | GABRA3 | ENSP00000329295 | ENSP00000359334 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | gamma-aminobutyric acid (GABA) A receptor, alpha 3; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel | 0.517 |
| NXPH3 | GLRA2 | ENSP00000329295 | ENSP00000218075 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | glycine receptor, alpha 2; The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing) | 0.621 |
| NXPH3 | KRT27 | ENSP00000329295 | ENSP00000301656 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | keratin 27; Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (By similarity) | 0.503 |
| NXPH3 | LCAT | ENSP00000329295 | ENSP00000264005 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | lecithin-cholesterol acyltransferase; Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16-0-18-2 or 18-O-18-2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-contain [...] | 0.503 |
| NXPH3 | NCDN | ENSP00000329295 | ENSP00000348394 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | neurochondrin; Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling (By similarity). Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin- concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth | 0.649 |
| NXPH3 | NPS | ENSP00000329295 | ENSP00000381105 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | neuropeptide S; Modulates arousal and anxiety. May play an important anorexigenic role. Binds to its receptor NPSR1 with nanomolar affinity to increase intracellular calcium concentrations (By similarity) | 0.749 |
| NXPH3 | NRXN1 | ENSP00000329295 | ENSP00000385142 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | neurexin 1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity) | 0.736 |
| NXPH3 | PLIN2 | ENSP00000329295 | ENSP00000276914 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | perilipin 2; May be involved in development and maintenance of adipose tissue (By similarity) | 0.602 |
| NXPH3 | RASGRP2 | ENSP00000329295 | ENSP00000338864 | neurexophilin 3; May be signaling molecules that resemble neuropeptides. Ligand for alpha-neurexins (By similarity) | RAS guanyl releasing protein 2 (calcium and DAG-regulated); Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway | 0.502 |
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