SERPINA7 protein (Homo sapiens) - STRING network view

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Size

small nodes:
protein of unknown 3D structure

large nodes:
some 3D structure is known or predicted

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

SERPINA7

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum (415 aa)

Predicted Functional Partners:

TTR

0.737

TRH

0.701

ALB

0.700

SLC16A2

0.674

TSPAN4

0.651

SHBG

0.636

TG

0.631

GDF15

0.560

TPO

0.507

ADCY10

0.489

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY10	ALB	ENSP00000356825	ENSP00000295897	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	albumin	0.814
ADCY10	GDF15	ENSP00000356825	ENSP00000252809	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	growth differentiation factor 15	0.418
ADCY10	SERPINA7	ENSP00000356825	ENSP00000329374	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	0.489
ADCY10	TSPAN4	ENSP00000356825	ENSP00000380552	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	tetraspanin 4	0.513
ALB	ADCY10	ENSP00000295897	ENSP00000356825	albumin	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	0.814
ALB	SERPINA7	ENSP00000295897	ENSP00000329374	albumin	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	0.700
ALB	SHBG	ENSP00000295897	ENSP00000369816	albumin	sex hormone-binding globulin	0.756
ALB	TG	ENSP00000295897	ENSP00000220616	albumin	thyroglobulin	0.824
ALB	TPO	ENSP00000295897	ENSP00000318820	albumin	thyroid peroxidase	0.568
ALB	TRH	ENSP00000295897	ENSP00000303452	albumin	thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. May promote hair shaft elongation, prolonge the hair cycle growth phase (anagen) and antagonized its termination by TGFB2. May also increase proliferation and inhibited apoptosis of hair matrix keratinocytes	0.561
ALB	TTR	ENSP00000295897	ENSP00000237014	albumin	transthyretin; Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain	0.823
GDF15	ADCY10	ENSP00000252809	ENSP00000356825	growth differentiation factor 15	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	0.418
GDF15	SERPINA7	ENSP00000252809	ENSP00000329374	growth differentiation factor 15	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	0.560
GDF15	TSPAN4	ENSP00000252809	ENSP00000380552	growth differentiation factor 15	tetraspanin 4	0.602
SERPINA7	ADCY10	ENSP00000329374	ENSP00000356825	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	adenylate cyclase 10 (soluble); Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation	0.489
SERPINA7	ALB	ENSP00000329374	ENSP00000295897	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	albumin	0.700
SERPINA7	GDF15	ENSP00000329374	ENSP00000252809	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	growth differentiation factor 15	0.560
SERPINA7	SHBG	ENSP00000329374	ENSP00000369816	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	sex hormone-binding globulin	0.636
SERPINA7	SLC16A2	ENSP00000329374	ENSP00000276033	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	solute carrier family 16, member 2 (thyroid hormone transporter); Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr (By similarity)	0.674
SERPINA7	TG	ENSP00000329374	ENSP00000220616	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; Major thyroid hormone transport protein in serum	thyroglobulin	0.631

page 1 of 3

Experiments

Cooccurrence

Textmining

Neighborhood

Coexpression

Fusion

Databases

© STRING Consortium 2017

Credits

Access

Info

About