Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | PCP4 | Purkinje cell protein 4; Probable regulator of calmodulin signaling (62 aa) | ||||||||||||
Predicted Functional Partners:
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 | ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 (678 aa) |
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0.668 | ||||||||||
 | CALM1 | calmodulin 1 (phosphorylase kinase, delta) (149 aa) |
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0.618 | |||||||||
 | ETS2 | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian); Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription (469 aa) |
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0.609 | ||||||||||
 | ACTR6 | ARP6 actin-related protein 6 homolog (yeast) (396 aa) |
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0.569 | ||||||||||
 | MRPS33 | mitochondrial ribosomal protein S33 (106 aa) |
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0.554 | ||||||||||
 | NRGN | neurogranin (protein kinase C substrate, RC3); Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity) (78 aa) |
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0.505 | ||||||||||
 | TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast); Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity) (98 aa) |
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0.473 | ||||||||||
 | DSCAM | Down syndrome cell adhesion molecule; Cell adhesion molecule that plays a role in neuronal self-avoidance. Promotes repulsion between specific neuronal processes of either the same cell or the same subtype of cells. Mediates within retinal amacrine and ganglion cell subtypes both isoneuronal self-avoidance for creating an orderly dendritic arborization and heteroneuronal self-avoidance to maintain the mosaic spacing between amacrine and ganglion cell bodies. Receptor for netrin required for axon guidance independently of and in collaboration with the receptor DCC. In spinal chord devel [...] (2012 aa) |
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0.471 | ||||||||||
 | PLEKHG5 | pleckstrin homology domain containing, family G (with RhoGef domain) member 5 (1083 aa) |
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0.453 | ||||||||||
 | RPS26 | ribosomal protein S26 (115 aa) |
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0.449 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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