RCAN2 protein (Homo sapiens) - STRING network view

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RCAN2

regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development (197 aa)

Predicted Functional Partners:

PPP3CA

0.923

THRSP

0.667

MYOM2

0.624

NIPAL3

0.599

GMFG

0.596

SRRM1

0.582

PPP3R1

0.577

PPP3CB

0.574

CABIN1

0.563

SIK2

0.562

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CABIN1	PPP3CA	ENSP00000263119	ENSP00000378323	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	0.997
CABIN1	PPP3CB	ENSP00000263119	ENSP00000378306	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.968
CABIN1	PPP3R1	ENSP00000263119	ENSP00000234310	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity	0.494
CABIN1	RCAN2	ENSP00000263119	ENSP00000329454	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.563
GMFG	MYOM2	ENSP00000472249	ENSP00000262113	glia maturation factor, gamma	myomesin 2	0.628
GMFG	RCAN2	ENSP00000472249	ENSP00000329454	glia maturation factor, gamma	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.596
MYOM2	GMFG	ENSP00000262113	ENSP00000472249	myomesin 2	glia maturation factor, gamma	0.628
MYOM2	RCAN2	ENSP00000262113	ENSP00000329454	myomesin 2	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.624
NIPAL3	RCAN2	ENSP00000363520	ENSP00000329454	NIPA-like domain containing 3	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.599
NIPAL3	SRRM1	ENSP00000363520	ENSP00000326261	NIPA-like domain containing 3	serine/arginine repetitive matrix 1; Part of pre- and post-splicing multiprotein mRNP complexes. Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3’-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequen [...]	0.607
PPP3CA	CABIN1	ENSP00000378323	ENSP00000263119	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	0.997
PPP3CA	PPP3CB	ENSP00000378323	ENSP00000378306	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	0.901
PPP3CA	PPP3R1	ENSP00000378323	ENSP00000234310	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity	0.999
PPP3CA	RCAN2	ENSP00000378323	ENSP00000329454	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.923
PPP3CA	SIK2	ENSP00000378323	ENSP00000305976	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	salt-inducible kinase 2; Phosphorylates ’Ser-794’ of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators	0.648
PPP3CB	CABIN1	ENSP00000378306	ENSP00000263119	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	calcineurin binding protein 1; May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals	0.968
PPP3CB	PPP3CA	ENSP00000378306	ENSP00000378323	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	protein phosphatase 3, catalytic subunit, alpha isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1	0.901
PPP3CB	PPP3R1	ENSP00000378306	ENSP00000234310	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity	0.989
PPP3CB	RCAN2	ENSP00000378306	ENSP00000329454	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	regulator of calcineurin 2; Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development	0.574
PPP3CB	SIK2	ENSP00000378306	ENSP00000305976	protein phosphatase 3, catalytic subunit, beta isozyme; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin	salt-inducible kinase 2; Phosphorylates ’Ser-794’ of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators	0.619

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